肿瘤预防与治疗2018，Vol.31Issue(1)：46-50,5.DOI:10.3969/j.issn.1674-0904.2018.01.008
佛山市南海区HIV感染者/AIDS患者中恶性肿瘤常见类型及生存分析
Common Types and Survival Analysis of Malignant Tumors in HIV/AIDS Population in Nanhai District of Foshan City
摘要
Abstract
Objective: To investigate the common types of malignant tumors and the survival status analysis in HIV/AIDS population in Nanhai District of Foshan City.Methods: Randomly select 41 cases of malignant tumors in HIV/AIDS population from January 1st, 2010 to March 31th, 2017 from managing and reporting system of the national disease surveillance as research group, and select all cases of non HIV-infected malignant tumors population as control group. Analyze the common types of HIV/AIDS associated malignant tumor, and Cox regression model was used for analyzing the prognosis of patients with HIV/AIDS complicated with malignant tumor. Results: The mean age of HIV patients with malignant tumor (41. 7 ± 7. 9) was significantly lower than that of non HIV malignant tumor (58. 7 ± 14. 8), and the difference was statistically significant (t = 7. 346, P < 0. 001). The common types of malignant tumor for HIV included lymphoma, cervical cancer and Kaposi's sarcoma, accounting for 65. 85％. The level of CD4 + T lymphocyte count in patients with malignant lymphoma, cervical cancer and other malignant tumors in HIV group was significantly lower than that in non HIV group, and the difference was statistically significant(P < 0. 05). The clinical stage of IV were the independent risk factors for prognostic death in patients with malignant tumor in HIV patients (RR = 3. 838, P < 0. 05);and while using HARRT therapy and anti-tumor treatment combination therapy (RR = 0. 062), the higher diagnosis of malignant tumor in CD4 + T lymphocyte count (RR = 0. 177) was a protective factor for the prognosis of patients with malignant tumor death of HIV (P < 0. 05). Conclusion: Malignant lymphoma, cervical cancer and Kaposi's sarcoma are the main types of malignant tumors in HIV/AIDS population. The number of CD4 + T lymphocytes in patients with HIV complicated with malignant tumor was significantly lower than that in non HIV patients. Clinical stage, treatment and CD4 + T lymphocyte level were the main factors affecting the survival of patients.关键词
HIV/AIDS/恶性肿瘤/生存/调查Key words
HIV/AIDS/Malignant tumors/Survival/Survey分类
医药卫生引用本文复制引用
李锦萍,管东波,黄喜明,朱小朴,潘宇韵..佛山市南海区HIV感染者/AIDS患者中恶性肿瘤常见类型及生存分析[J].肿瘤预防与治疗,2018,31(1):46-50,5.基金项目
佛山市医学类科技攻关项目(编号:2014AB000072) （编号:2014AB000072）
