山东医药2018，Vol.58Issue(24)：18-21,4.DOI:10.3969/j.issn.1002-266X.2018.24.005
胰腺导管细胞癌组织CSF3R基因表达对患者预后的影响及其机制
Expression and significance of CSF3R gene in pancreatic ductal adenocarcinoma
摘要
Abstract
Objective To investigate the relationship between the expression of granulocyte colony-stimulating factor-3 receptor (CSF3R) gene and the prognosis of patients with pancreatic ductal adenocarcinoma , and to analyze the correlated genes and cellular pathways.Methods The corresponding cancer datasets included 132 samples were extracted from the public database GEO to obtain the patients’ information and mRNA expression data.The survival curve was drawn by Kap-lan-Meier method using the R2 bioinformatics analysis platform, and the relationship between the expression of CSF 3R and the prognosis of the patients was analyzed.Genes significantly associated with CSF 3R expression were enriched and analyzed for KEGG pathways and GO pathways.Results The datasets showed a significant negative correlation between CSF 3R mRNA expression level and the overall survival rate (P＜0.05).The overall survival rate was higher in patients with high CSF 3R expression than in patients with low CSF3R expression (P＜0.05).In addition, there were 6 521 genes associated with CSF3R expression, during which, 3 040 genes were positively correlated and 3 481 genes were negatively correlated.KEGG analysis showed that 27 gene were highly expressed (C1QA, C1QB, C1QC, C2, C3AR1, C5, C5AR1, FCAR, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FGG, FPR1, FPR2, FPR3, HLA-DMB, HLA-DQA1, HLA-DQB1, ICAM1, ITGAM, ITGB2, MASP1, MASP2, MBL2, PLG, SELPLG), and they involved only one signaling pathway, staphylococcus aureus infection.GO analysis found that CSF3R and its related genes were mainly related to cell response to stimulation, immune response, RAS regu-lation, and pancreas development.Conclusion CSF3R expression is negatively correlated with the overall survival rate of pa-tients with pancreatic ductal adenocarcinoma, and it may be a potential molecular marker for the study of prognosis of patients.关键词
胰腺导管细胞癌/粒细胞集落刺激因子3受体/基因芯片/总体生存率Key words
pancreatic ductal adenocarcinoma/granulocyte colony-stimulating factor-3 receptor/microarray/overall survival rate分类
医药卫生引用本文复制引用
方天逸,王宇夫,林轩,王浩,崔云甫..胰腺导管细胞癌组织CSF3R基因表达对患者预后的影响及其机制[J].山东医药,2018,58(24):18-21,4.基金项目
国家自然科学基金资助项目(61572227) . （61572227）
