陕西中医2018，Vol.39Issue(7)：910-912,3.DOI:10.3969/j.issn.1000-7369.2018.07.030
丹参川芎嗪注射液联合黄芪注射液对早期糖尿病肾病患者尿UAER、UACR、β2-MG及血清IL-6、IL-18、TNF-α的影响研究
The study of Danshen Ligustrazine injection combined with astragalus injection on urinary UAER-UACR-β 2-MG and Serum IL-6 IL-18 TNF-α in patients with early diabetic nephropathy
潘险峰 1袁仲飞 1黄国威 1唐妮 1李瑛2
作者信息
- 1. 重庆市开州区人民医院肾内科,重庆405400
- 2. 重庆市开州区人民医院药剂科,重庆405400
- 折叠
摘要
Abstract
Objective :to observe the effect of Dan shen ligustrazine injection combined with astragalus injec-tion on inflammatory factors in patients with early diabetic nephropathy .Methods :the clinical data of 101 patients with early diabetic kidney were retrospectively analyzed and divided into two groups :control group and study group . The control group (n=45) was treated with Danshen ligustrazine injection and the study group (n=56) was treated with astragalus injection on the basis of the control group .After 4 weeks of treatment ,the clinical efficacy of the two groups was observed ,and the scores of TCM symptoms in the two groups were compared .The levels of UACR-β 2-MG and serum IL-6 ,IL-18 ,TNF-α were compared between the two groups .Results :the total clinical effective rate of the control group was 77 .78% weeks after treatment ,and the total effective rate of the study group was 88 .24%, which was significantly higher than that of the control group (P＜0 .05) ,and the levels of UAER-UACR ,β 2-MG and serum in the two groups before treatment were significantly higher than those in the control group (P＜0 .05) . There was no significant difference in the level of IL-18 and TNF-α between the two groups (P＞0 .05) .After treat-ment ,the levels of UAR ,β 2-MG and serum IL-18NF-a were significantly improved in the two groups .Statistical differences between groups significance (P＜ 0 .05) .Conclusion :Dan shen ligustrazine injection combined with as-tragalus injection in the treatment of early diabetic nephropathy patients can effectively improve the symptoms of tra-ditional Chinese medicine improve the renal function of patients with lower inflammatory factors in the body the clin-ical effect is obvious .关键词
糖尿病肾病/中西医结合疗法/川芎嗪注射液/黄芪注射液Key words
Diabetic nephropathy/integrated Chinese traditional and western medicine therapy/Danshen Li-gustrazine injection/Astragalus injection分类
医药卫生引用本文复制引用
潘险峰,袁仲飞,黄国威,唐妮,李瑛..丹参川芎嗪注射液联合黄芪注射液对早期糖尿病肾病患者尿UAER、UACR、β2-MG及血清IL-6、IL-18、TNF-α的影响研究[J].陕西中医,2018,39(7):910-912,3.
