同济大学学报（医学版）2018，Vol.39Issue(3)：7-12,6.DOI:10.16118/j.1008-0392.2018.03.002
高频超声心动图评价IGFBP-4转基因小鼠心肌梗死后心脏功能的变化
Assessment of cardiac function of IGFBP-4 transgenic mice with myocardial infarction by high-frequency echocardiography
摘要
Abstract
Objective To assess the cardiac function of insulin-like growth factor binding protein-4 ( IGFBP-4 ) transgenic mice with myocardial infarction by high-frequency echocardiography. Methods The myocardial infarction was induced by ligation of left anterior descending coronary artery in ICR male mice ( control group, n＝30) and IGFBP-4 transgenic mice ( n＝30).The cardiac function was assessed by high-frequency echocardiography before and 1, 2 weeks after modeling. The mice were sacrificed for pathological examination and left ventricular mass ( LVM) weighing. The relevance of LVM value measured by high-frequency echocardiography and that of postmortem examination was analyzed. Results Echocardiography showed that (ejection fraction)EF and (fractional shortening)FS value decreased (P＜0.05) while (left ventricular internal diameter at end diastolic)LVIDd and (left ventricular internal diameter at end systolic) LVIDs increased markedly ( P＜0.05) after modeling. And the reduction of EF and FS value in IGFBP-4 transgenic mice was significantly lower than that in the control group(P＜0.05); the enlargement of LVIDd and LVIDs was also lower than that of control group (P＜0. 05). The LVM value measured by high-frequency echocardiography was closely correlated with that examined by postmortem both in control group (r＝0.89, P＜0.01) and in IGFBP4 group (r＝0.93, P＜0. 01).Conclusion The cardiac function change of IGFBP-4 transgenic mice group can be accurately assessed by high-frequency echocardiography.关键词
高频超声心动图/胰岛素样生长因子结合蛋白-4/小鼠/心肌梗死Key words
high-frequency echocardiography/insulin-like growth factor binding protein-4/mice/myocardial infarction分类
医药卫生引用本文复制引用
张宇辉,刘怡,夏良华,陈明,金佳美,沃达..高频超声心动图评价IGFBP-4转基因小鼠心肌梗死后心脏功能的变化[J].同济大学学报（医学版）,2018,39(3):7-12,6.基金项目
上海市卫计委科研项目(20154Y0073) （20154Y0073）
