同济大学学报（医学版）2018，Vol.39Issue(3)：48-52,5.DOI:10.16118/j.1008-0392.2018.03.009
甲状腺功能正常冠心病患者的血清促甲状腺激素水平与冠状动脉病变严重程度的相关性
Association of serum thyroid stimulating hormone levels and disease severity in coronary heart disease patients with normal thyroid function
摘要
Abstract
Objective To investigate the correlation between serum thyroid stimulating hormone ( TSH) and the severity of coronary atherosclerotic heart disease ( CAD ) in patients with normal thyroid function. Methods Total 274 subjects with suspicious coronary heart disease and normal thyroid function underwent coronary angiography during November 2015 to January 2016. The clinical data of patients were collected and analyzed, including body mass index ( BMI) , waist circumference (WC), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride ( TG) , low density lipoprotein-cholesterol ( LDL-C) , high density lipoprotein-cholesterol (HDL-C), systolic blood pressure(SBP), diastolic blood pressure (DBP), triiodothyronine (T3), thyroxine ( T4) , free triiodothyronine ( FT3) , free thyroxine ( FT4) , thyroid-stimulating hormone ( TSH). Spearman simple correlation analysis and multivariate Logistic regression analysis was applied to examine the correlation between TSH levels and the severity of CAD. Results There was no significant difference in TSH level between the CAD group and non-CAD group (P＝0. 942). The TSH levels in CAD patients with severe lesion were significantly higher than those with mild lesion ( P＝0. 002). Spearman simple correlation analysis showed that TSH levels were positive correlated with the severity of coronary artery disease(r＝0. 128,P＝0. 034).Multivariate Logistic regression analysis showed that age (OR＝1. 025, 95%CI: 1. 000-1. 050) and TSH level (OR＝1. 454, 95%CI: 1. 123-1. 884) were independent risk factors for severe coronary lesions.Conclusion The serum TSH level is not a risk factor for coronary heart disease in individuals with normal thyroid function. But the serum TSH level is correlated with the severity of coronary artery lesions in CAD patients.关键词
促甲状腺激素/冠心病/危险因素Key words
thyroid stimulating hormone/coronary artery disease/risk factors分类
医药卫生引用本文复制引用
曹福明,王华,唐兆生,冯波..甲状腺功能正常冠心病患者的血清促甲状腺激素水平与冠状动脉病变严重程度的相关性[J].同济大学学报（医学版）,2018,39(3):48-52,5.基金项目
上海市浦东新区卫生系统优秀青年医学人才计划(PWRq2012-08) （PWRq2012-08）
