同济大学学报（医学版）2018，Vol.39Issue(3)：59-63,5.DOI:10.16118/j.1008-0392.2018.03.011
不同高危型HPV感染与宫颈癌及宫颈高级别病变的相关性
Correlation between high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions
摘要
Abstract
Objective To examine the correlation between high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Methods From January 2014 to October 2016, a total of 1 195 HPV infected patients admitted at Ningbo Women’s &Children’s Hospital were enrolled in this study. The HPV subtypes involved in this study were HPV16, 18, 31, 33, 35, 52 and 58. All cases had a confirmed cervical pathological result. Univariate analysis and multivariate Logistic regression analysis was used to analyze the correlation between the high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions. Results The detection rates of cervical cancer in seven HPV subtypes infection cases were: HPV18 ( 5. 78%), HPV16 ( 5. 39%), HPV58 ( 1. 71%), HPV31 (1. 35%), HPV52(0. 39%), HPV33(0%) and HPV35(0%). The detection rates of high-grade cervical lesions in seven HPV subtypes infection cases were: HPV33 ( 48. 04%), HPV16 ( 47. 86%), HPV58 (29. 56%), HPV31(24. 65%), HPV18(23. 31%), HPV35(22. 58%) and HPV52(21. 26%). The risk of cervical cancer in the case of HPV16 infection was the greatest (OR＝3. 831,P＜0. 05), followed by HPV18 infection (OR＝2. 586,P＜0. 05). The risk of high-grade cervical lesions in the case of HPV16 infection was still the greatest (OR＝3. 831,P＜0. 05), followed by HPV33 (OR＝2. 531,P＜0. 05). Conclusion The correlations between various high-risk HPV subtypes infection and cervical cancer/high-grade cervical lesions are different.HPV16 and 18 infection are likely to be associated with cervical cancer, while HPV16 and 33 infection are likely to be associated with high-grade cervical lesions.关键词
高危型HPV/亚型/宫颈癌/宫颈高级别病变Key words
high-risk HPV/subtype/cervical cancer/high-grade cervical lesions分类
医药卫生引用本文复制引用
张毅,王建军..不同高危型HPV感染与宫颈癌及宫颈高级别病变的相关性[J].同济大学学报（医学版）,2018,39(3):59-63,5.基金项目
上海市科委项目(16411950200) （16411950200）
