同济大学学报（医学版）2018，Vol.39Issue(3)：74-78,5.DOI:10.16118/j.1008-0392.2018.03.014
角膜塑形镜对不同屈光度青少年近视患者的疗效分析
Efficacy and safety of orthokeratology in adolescent myopia with different diopter
摘要
Abstract
Objective To evaluate the efficacy and the safety of orthokeratology( OK) in adolescent myopia with different diopter. Methods One hundred and sixty-two adolescents with myopia ( 301 eyes) , 68 males and 94 females were enrolled in the study. According to the equivalent spherical degree, there were 98 eyes with －0. 50-－2. 00 D (group A), 155 eyes with －2. 25-－4. 00 D (group B) and 48 eyes with 4. 25-－6. 00 D ( group C). The patients wore OK lens 7. 5-10 h every night. The uncorrected eyesight, axial length, corneal keratometry, corneal thickness, corneal endothelial cell change and slit lamp examination before and 6, 12 months after wearing OK lens were documented and analyzed. Results The uncorrected visual acuity was significant increased after wearing lenses for 6 and 12 months in all three groups ( P＜0. 001 ) ; while there was significant difference in the increased value of visual acuity among three groups( P＜0. 001). There were significant differences in central corneal flat keratometry ( FK) and steep keratometry ( SK) before and 6, 12 months after wearing OK lens in all three groups( P＜0. 001). There were significant differences in FK and SK 12 months after wearing OK lens between group A and group B, between group A and group C( P＜0. 001 ) ; while but there was no significant difference between group B and group C ( P＞0. 05). There was significant difference in eye axis of group A before and after wearing OK lens for 6 and 12 months( P＜0. 001) ; but there was no significant difference in group B and group C ( P＞0. 05). There was significant difference in the increase of axial length after wearing OK lens between group A and group B, between group A and group C ( P＜0. 001 ) , but no difference between group B and group C ( P＞0. 05 ). There was no significant difference in central corneal thickness and corneal endothelial cell change before and after wearing OK lens in all three groups ( P＞0. 05 ). There were 34 cases of positive corneal fluorescein staining after 12 months of wearing OK lens: 3 cases in group A ( 3. 06%) , 21 in group B ( 13. 46%) and 10 in group C ( 20. 83%). Conclusion Wearing OK lens is effective and safe to control the development of adolescent myopia, and it has better effect for myopia patients with the diopter over －2 D.关键词
角膜塑形镜/屈光度/眼轴/并发症/安全性Key words
Orthokeratology/Refraction/axial length/complication/safety分类
医药卫生引用本文复制引用
张珍,栗莉,史胜,李艳红,梁秀玮,于靖..角膜塑形镜对不同屈光度青少年近视患者的疗效分析[J].同济大学学报（医学版）,2018,39(3):74-78,5.基金项目
国家自然基金面上项目(81470648) （81470648）
