世界中医药2018，Vol.13Issue(6)：1456-1460,5.DOI:10.3969/j.issn.1673-7202.2018.06.036
温润辛金培本方治疗支气管哮喘慢性持续期的随机对照双盲研究
A Randomized Controlled Double－Blind Study of the Treatment of Bronchial Asthma Chronic Persistent Period by Wenrun Xinjin Peiben Prescription
摘要
Abstract
Objective:To analyze and study the curative effect and safety in the treatment of chronic persistent period asthma by Wenrun Xinjin Peiben prescription.Methods:A total of 130 patients with chronic persistent bronchial asthma from five hospitals from April 2009 to November 2009 were selected.They were randomly divided into the treatment group and the control group , with 65 cases in each group.On the basis of routine treatment of western medicine , the treatment group was treated with Wenrun Xinjin Peiben prescription, and the control group was given a placebo.The treatment course was 6 weeks.The efficacy and safety indexes of the two groups were compared.Results:The baseline situation of the patients in the treatment group and the control group was comparable.There was no obvious abnormality in the safety indexes of the patients in the treatment group before and after the treat －ment, and no adverse reaction occurred during the medication.The results of main symptoms and signs curative effect in the two groups showed that in the treatment group 2 cases were under control, 9 cases markedly effective , 26 cases effective, 28 cases not effective, while in the control group 3 cases were under control , 1 case markedly effective , 15 cases effective, and 46 cases not ef－fective.The curative effect of treatment group was better than the control group (P＜0.01).The effectiveness and efficiency eval－uation of main symptoms and signs showed that the patients in the treatment group were significantly higher than those of the control group (P＜0.05, P＜0.01).The pulmonary function index FEV 1/FVC in the treatment group was significantly better than that in the control group (P＜0.05) after treatment.The FEV1in the treatment group was significantly improved after treatment compared with that before treatment (P＜0.05).Conclusion:Satisfactory curative effect had been showed in the treatment of chronic persis－tent asthma by Wenrun Xinjin Peiben prescription , with a high safety and no obvious adverse reaction.It has a positive effect on alleviating the symptoms of the patients , improving the lung function and the prognosis of the disease.关键词
温润辛金培本方/支气管哮喘/慢性持续期/随机对照双盲/不良反应Key words
Wenrun Xinjin Peiben Prescription/Bronchial asthma/Chronic persistent period/Randomized controlled double－blind/Adverse reactions分类
医药卫生引用本文复制引用
史琦,杨璐,孔艳华,李友林..温润辛金培本方治疗支气管哮喘慢性持续期的随机对照双盲研究[J].世界中医药,2018,13(6):1456-1460,5.基金项目
北京市科学技术委员会"十病十药"研发项目(Z161100001816004) （Z161100001816004）
国家中医药管理局中医药行业科研专项项目(7－21) （7－21）
中医药防治过敏性疾病北京市重点实验室(BZ0321) （BZ0321）
