山西医科大学学报2018，Vol.49Issue(6)：614-617,4.DOI:10.13753/j.issn.1007-6611.2018.06.006
FOXP3与TGF-β1在卵巢异位子宫内膜中的表达及意义
Expression and significance of FOXP3 and TGF-β1 in ovarian endometriotic tissues
赵娟 1樊晓慧 1韩晓兵1
作者信息
- 1. 西安交通大学第一附属医院妇产科,西安 710061
- 折叠
摘要
Abstract
Objective To explore the expression and significance of FOXP3 and TGF-β1 expression in ovarian endometriotic tissues. Methods FOXP3 and TGF-β1 expression was detected in 40 cases of ovarian endometriotic tissues,40 cases of normal endometrium tissues and 40 cases of normal ovarian tissues by immunohistochemistry(IHC),and their relationship was investigated. Results FOXP3 showed high expression in ovarian endometriotic tissues,significantly higher than that of normal endometrium tissues (χ2＝22. 55,P＝0. 000)and normal ovarian tissues(χ2＝14. 70,P＝0. 000). TGF-β1 showed moderate or strong positive expression in ovarian endometriotic tissues,and the expression was significantly higher than that in normal endometrium tissues (χ2＝8. 12,P ＝0. 010)and normal ovarian tissues(χ2＝4. 34,P＝0. 037). Spearman correlation analysis showed that the expression of FOXP3 was positively correlated with the expression of TGF-β1 in ovarian endometriotic tissues(r＝0. 667,P＝0. 001). Conclusion The expres-sion of FOXP3 and TGF-β1 in ovarian endometriotic specimen is high and shows positive correlation,suggesting that they have syner-gistic effect in the occurrence and development of EMS.关键词
子宫内膜异位症/FOXP3/TGF-β1Key words
endometriosis/FOXP3/TGF-β1分类
医药卫生引用本文复制引用
赵娟,樊晓慧,韩晓兵..FOXP3与TGF-β1在卵巢异位子宫内膜中的表达及意义[J].山西医科大学学报,2018,49(6):614-617,4.
