摘要
Abstract
Objective To investigate the clinical features of anti-platelet drug-related nonvariceal upper gastrointestinal bleeding (NVUGIB)and its influencing factors. Methods The clinical data of 496 patients with NVUGIB in First Hospital of Shanxi Medical University from January 2015 to December 2017 were analyzed retrospectively,and were divided into anti-platelet drugs group and non-anti-platelet drugs group according to the use of anti-platelet drugs before bleeding. The clinical data associated with NVUGIB were compared between two groups. The related factors were analyzed. Results There were 134 patients in anti-platelet drugs group and 364 patients in non-anti-platelet drugs group. There was no significant difference in patient gender,drinking history,atrial fibrillation, connective tissue disease history,oral warfarin history,oral non-steroidal anti-inflarnmatory drugs history in addition to aspirin,bleeding site in the endoscopic and degree of anemia between two groups(P＞0. 05). The severity of bleeding and first symptoms of bleeding showed statistical difference between two groups(P＜0. 05). Older age,history of smoking,history of peptic ulcer bleeding,combination with hypertension,coronary heart disease and cerebral infarction accounted for a large proportion in anti-platelet drug-related NVUGIB group,and there was statistical difference between two groups(P＜0. 05). Age(＞60 years),history of peptic ulcer bleeding,combina-tion with hypertension,coronary heart disease and cerebral infarction were independent risk factors for anti-platelet drug-related NVUGIB. Conclusion The anti-platelet drug-related NVUGIB mainly occurs in old patients. The patients often exhibit melaena and anemia caused by recessive bleeding as the first symptoms of bleeding,lack of abdominal pain and other gastrointestinal symptoms be-fore bleeding,and severe bleeding is more found in anti-platelet drug-related NVUGIB group. Many factors influence NVUGIB caused by anti-platelet drugs. When using anti-platelet drugs,many measures should be taken,such as paying attention to risk factors,taking precautions,regularly monitoring bleeding indicators.关键词
抗血小板药物/非静脉曲张上消化道出血/危险因素/回顾性研究Key words
anti-platelet drugs/nonvariceal upper gastrointestinal bleeding/risk factors/retrospective study分类
医药卫生
