山西医科大学学报2018，Vol.49Issue(6)：674-677,4.DOI:10.13753/j.issn.1007-6611.2018.06.018
长链非编码RNA XIST在神经胶质瘤中的表达和临床意义
The expression of long non-coding RNA XIST in glioma and its clinical significance
摘要
Abstract
Objective To investigate the expression of long non-coding RNA XIST in glioma tissues and its relationship with clinical prognosis. Methods The expression level of XIST in 64 glioma tissues and normal brain tissues was detected by RT-PCR,and its correlation with clinicopathological features and prognosis of glioma patients was analyzed. Results The expression level of XIST in glioma tissue was significantly higher than that of normal brain tissue(2. 88 ± 0. 73 vs 1. 00 ± 0. 73,P＝0. 001 2). The expression level of XIST in high grade gliomas was significantly higher than that in low grade gliomas(4. 20 ± 1. 09 vs 2. 88 ± 0. 73,P＝0. 013 4). The expression level of XIST was closely related to WHO grade and KPS score. However,XIST expression level had no significant correla-tion with age,sex,tumor size and the number of tumor. The results of Kaplan-Meier analysis showed that the survival rate of patients in XIST high expression group was significantly lower than that in XIST low expression group(P＝0. 007). The high expression of XIST,advanced WHO grade,KPS＜80 points were the independent risk factors for predicting poor prognosis in glioma patients(P＜0. 05). Conclusion The expression of XIST in glioma tissues is significantly elevated and correlated with the clinical prognosis of pa-tients. XIST might be used as a novel biomarker for predicting the prognosis of glioma and a potential therapeutic target.关键词
神经胶质瘤/长链非编码RNA/XIST/预后Key words
glioma/long non-coding RNA/XIST/prognosis分类
医药卫生引用本文复制引用
宋千,庞宏刚,祁磊,梁晨,王拓,王伟,郭世文..长链非编码RNA XIST在神经胶质瘤中的表达和临床意义[J].山西医科大学学报,2018,49(6):674-677,4.基金项目
陕西省自然科学基金面上项目(2015JM8398) （2015JM8398）
