陕西医学杂志2018，Vol.47Issue(7)：931-933,936,4.DOI:10.3969/j.issn.1000-7377.2018.07.036
噻托溴铵联合大剂量沙美特罗氟替卡松治疗重度支气管哮喘合并COPD稳定期疗效研究
Analysis of the curative effect of tiotropium combined with high dose of salmeterol fluticasone propionate in the treatment of patients with severe bronchial asthma combined with COPD in stable phase
摘要
Abstract
Objective:To study and analyze the curative effect of tiotropium combined with high dose of salmeterol fluticasone in the treatment of patients with severe bronchial asthma combined with COPD in stable phase.Methods:The treatment of severe bronchial asthma combined with COPD patients of 158 cases were studied.On the basis of the digital random table method,158 patients were divided into observation group and control group each with 79 cases in each,the control group was given tiotropium bromide and moderate dose salmeterol fluticasone,the observation group was given tiotropium bromide and high-dose salmeterol fluticasone,evaluated the efficacy of the two groups after 1 years.Results:The control rate of asthma in the observation group was 45.57% and the total control rate was 98.73%,which were signif-icantly higher than the control group of 21.52% and 88.61%,the difference was statistically significant (P ＜ 0.05).Af-ter treatment,the observation group of FEV1% was expected to increase and FEV1 values were significantly higher than those of the control group.PEF level was significantly lower than that of the control group,the difference was statistically significant (P ＜ 0.05).After treatment,the onset time of the observation group was significantly less than the control group,onset interval was significantly higher than the control group,the difference was statistically significant (P ＜ 0. 05).The observation group’s the total incidence of adverse reaction was 5.06%,compared with 7.59% in the control group,the difference was not statistically significant (P ＞ 0.05).Conclusion:The application of Tiotropium bromide and large doses of salmeterol fluticasone propionate on severe asthma combined efficacy in the treatment of patients with chronic obstructive pulmonary disease (COPD) better,and can effectively improve the patient's lung function and clinical symptoms, safety is high,it is worth to give recommendation.关键词
哮喘/并发症/肺疾病,慢性阻塞性/药物疗法/噻托溴铵/@沙美特罗氟替卡松Key words
Asthma/complications/Pulmonary disease ,chronic obstructive/drug therapy/Tiotropium bro-mide/@Salmeterol fluticasone分类
医药卫生引用本文复制引用
谢刚强,唐甦,马军党,李洁..噻托溴铵联合大剂量沙美特罗氟替卡松治疗重度支气管哮喘合并COPD稳定期疗效研究[J].陕西医学杂志,2018,47(7):931-933,936,4.基金项目
陕西省安康市科技计划项目(2015AK04-13) （2015AK04-13）
