实用肝脏病杂志2018，Vol.21Issue(4)：505-508,4.DOI:10.3969/j.issn.1672-5069.2018.04.005
PRETEXT分期系统对儿童肝母细胞瘤病理学分型和疗效评估的价值分析
Application of PRETEXT staging system in evaluating treatment response of children with hepatoblastoma
摘要
Abstract
Objective To evaluate the value of PRETEXT staging system and CT imaging features in evaluating treatment response of pediatric hepatoblastoma (HB). Methods The multi-detector CT imaging features in 47 children with pathologically confirmed HB were retrospectively reviewed between January 2013 and August 2016. The consistency between PRETEXT stage and post-surgical pathological grade was assessed. The CT imaging findings, including tumor margin,morphology,intra-tumor hemorrhage,calcification and intra-tumor cystic necrosis, and pathological grades was evaluated. Results Out of 47 children with HB,30 (63.8%) were pathological-proven epithelial,and 17 (36.2%) with epithelial-mesenchymal type;eight children with HB,including 6 with PRETEXT stage II and 2 with PRETEXT stage III, received surgery without chemotherapy,and their PRETEXT stages was completely consistent with pathological-proven grade, and the accuracy rate between POSTTEXT stages and pathological grades reached 79.5% (31/39) in 39 children receiving surgery after chemotherapy;the overall accuracy of PRETEXT stage was 83.0% as compared with post-surgical pathological grade;out of ten children with tumor calcification,eight was with epithelial-mesenchymal type tumor, much higher than in with epithelial type (x2=8.313, P=0.004). Conclusion The PRETEXT stage is well consistent with post-surgical grade, and it might predict the pathological grade in consideration of specific image findings,which is helpful in determining management strategy of children with HB.关键词
肝母细胞瘤/儿童/PRETEXT分期/计算机X线体层摄影术Key words
Hepatoblastoma/Children/PRETEXT staging system/X-ray computed tomography引用本文复制引用
张财源,李金凝,刘欢欢,汪登斌..PRETEXT分期系统对儿童肝母细胞瘤病理学分型和疗效评估的价值分析[J].实用肝脏病杂志,2018,21(4):505-508,4.基金项目
科技部国家重点研发计划项目(编号:2017YFC0109003) （编号:2017YFC0109003）
