生殖医学杂志2018，Vol.27Issue(7)：617-622,6.DOI:10.3969/j.issn.1004-3845.2018.07.003
人工黄体期控制性促排卵方案在多囊卵巢综合征患者实施IVF/ICSI中的应用价值
Clinical value of controlled hyperovulation in artificial luteal phase in IVF/ICSI cycles of patients with polycystic ovary syndrome
王昊昱 1骆丽华 1汤文娟 1黄玲莉 1吴莉 1金琪 1童先宏 1金仁桃 1刘雨生1
作者信息
- 1. 中国科学技术大学附属第一医院(安徽省立医院)生殖医学中心,合肥 230001
- 折叠
摘要
Abstract
Objective:To investigate the clinical value of controlled hyperovulation(COH)in artificial luteal phase in IVF/ICSI cycles of patients with polycystic ovary syndrome(PCOS). Methods: A total of 227 patients with PCOS undergone IVF/ICSI in our hospital from June 2016 to June 2017 were divided into two groups:112 patients adopted artificial luteal phase protocol with medroxyprogesterone acetate (MPA ) in early follicular phase and 115 patients adopted the long protocol.The outcomes of COH and frozen-thawed embryo transfer were retrospectively analyzed. Results:No early LH peak occurred in both groups.The amount [(28.65 ± 11.27)vs.(34.56 ± 15.55)ampoule]and days [(12.65±3.64 vs.(15.01±4.28)days]of gonadotropin(Gn)used in artificial luteal phase protocol group were significantly lower than the long protocol group(P＜0.05).The levels of LH[(2.81±2.50)vs.(1.62±1.49)U/L]and E2[(15 121.44±4 100.99)vs.(12 635.82±5 178.75)pmol/L], the number of mature oocytes [(11.51±6.73)vs.(9.83±5.87)]and the 2PN fertilization rate(67.50% vs.59.45%)in artificial luteal phase protocol group were significantly higher than the long protocol group (all P＜0.05 ).Severe ovarian hyperstimulation syndrome (OHSS)rate (0.00% vs.5.22%)in artificial luteal phase protocol group was significantly lower than the long protocol group(P＜0.05).There was no significant difference in number of retrieved oocytes [(14.26±8.47)vs.(13.50±8.44)],cycle cancellation rate due to no available embryos(5.36% vs.7.83%),high-quality embryo rate(57.45% vs.57.16%),the implantation rate(47.46% vs.43.07%),ongoing pregnancy rate in frozen-thawed embryo transfer(63.64% vs.62.03%)and the abortion rate(7.14% vs.4.08%)between two groups(P＞0.05). Conclusions:COH protocol in PCOS patients with artificial luteal phase can achieve the same effect as long protocol.Compared with the long protocol,artificial luteal phase protocol can significantly reduce the incidence of OHSS,the amount and days of gonadotropin,while it can increase the number of mature oocytes and the 2PN fertilization rate.Thus,artificial luteal phase protocol is effective and safe,more economical for patients with PCOS.关键词
体外受精-胚胎移植/人工黄体期/控制性促排卵/多囊卵巢综合征Key words
In vitro fertilization/Artificial luteal phase/Controlled hyperovulation/Polycystic ovary syndrome引用本文复制引用
王昊昱,骆丽华,汤文娟,黄玲莉,吴莉,金琪,童先宏,金仁桃,刘雨生..人工黄体期控制性促排卵方案在多囊卵巢综合征患者实施IVF/ICSI中的应用价值[J].生殖医学杂志,2018,27(7):617-622,6.
