生殖医学杂志2018，Vol.27Issue(7)：647-652,6.DOI:10.3969/j.issn.1004-3845.2018.07.009
我国孕期风疹病毒IgM检测及其意义的Meta分析
Detection and clinical significance of anti-rubella IgM antibody among pregnant women in China:a Meta-analysis
摘要
Abstract
Objective:To evaluate the positive rate of anti-rubella IgM antibody in early pregnancy,and the relationship between the positive rate of anti-rubella IgM antibody and gestational times as well as early abortion. Methods: Databases including Cochrane Library,PubMed,CBM,CNKI,VIP and Wanfang Databases were searched to identify the document related to the detection of anti-rubella IgM antibody during pregnancy from the establishment of databases to June 2017.Meta-analyses were performed by using the STATA software after the selection of studies,extraction of data and assessment of quality based on the inclusive and exclusive criteria. Results:Nine papers including 53270 women were selected.Among them,1 923(3.61%)women with positive anti-rubella IgM antibody were found.Five papers related the positive rate of anti-rubella IgM antibody with gestational times were included.The statistical results showed that the positive rate of anti-rubella IgM antibody was increased with the gestational times [OR=0.316;95% C I (0.210,0.475);P＜0.001].Four papers with the relationship between the positive rate of anti-rubella IgM antibody and early abortion were included.The results showed that the risk of early abortion was significantly higher in pregnant women with positive anti-rubella IgM antibody than IgM negative pregnant women [OR=3.184;95% CI (1.874,5.410;P＜0.001]. Conclusions: Serologic screening on rubella virus in pregnant women should be strengthened to prevent birth defects and adverse pregnancy outcomes.关键词
Meta分析/风疹病毒/孕期/IgMKey words
Meta-analysis/Rubella virus/Gestation/IgM antibody引用本文复制引用
李学敬,茅群霞,裴开颜..我国孕期风疹病毒IgM检测及其意义的Meta分析[J].生殖医学杂志,2018,27(7):647-652,6.基金项目
国家科技支撑计划课题(2012BAI41B08) （2012BAI41B08）
