武警医学2018，Vol.29Issue(1)：10-13,4.
特发性膜性肾病的临床特征与治疗策略
Clinical features and treatment strategies of idiopathic membranous nephropathy
王倩 1高燕 2李林倩 1李向萌 1陈玉杰 1张海松 2邢亮3
作者信息
- 1. 071000 保定, 河北大学医学院
- 2. 071000 保定, 河北大学附属医院肾内科
- 3. 071000 保定, 河北大学附属医院 病理科
- 折叠
摘要
Abstract
Objective To explore the clinical features and treatment of idiopathic membranous nephropathy (IMN). Methods The clinical and renal pathological data of 336 patients with IMN treated at the Affiliated Hospital of Hebei University between July 2015 and June 2017 was analyzed retrospectively. Results (1) Among the 336 cases of IMN patients, the ratio of urban patients to rural ones was 0.29: 1.283 of these patients were farmers, whose percentage was significantly higher than that of other occupations. This disease was more prevalent in spring than in other seasons. (2)IMN patients were characterized by nephrotic syndrome and chronic nephritis syndrome, with high blood pressure and microscopic hematuria. (3) Most of the patients were in stage 1 according to pathological staging, accounting for 58.6％. 63.1％ of the patients had renal tubule-interstitial damage. Immunofluorescence showed that the immune complex was mainlv formed by IgG and C3. (4)Compared with the young and middle-aged groups, high blood pressure was more prevalent in the elder group. The proportion of hematuria in the middle-aged group was higher than in other groups. There was no statistically significant difference in diastolic blood pressure, anemia, albumin, serum creatinine, total cholesterol, triglyceride and glomerulosclerosis integrals between the three groups. (5) With the increase of pathological staging, the proportion of patients with anemia increased gradually, so did the glomerulosclerosis integral. There was no statistically significant difference between the pathological stages in the percentage of males, the proportion of hypertension, blood urine, 24-hour urine protein, blood albumin, serum creatinine and eGFR. Conclusions The clinical treatment of elders, male patients, mass proteinuria, those with high pathological staging, renal tubule and interstitial fibrosis is more important.关键词
特发性膜性肾病/临床表现/病理特征Key words
idiopathic membranous nephropathy/clinical manifestation/pathological feature分类
临床医学引用本文复制引用
王倩,高燕,李林倩,李向萌,陈玉杰,张海松,邢亮..特发性膜性肾病的临床特征与治疗策略[J].武警医学,2018,29(1):10-13,4.
