武警医学2018，Vol.29Issue(1)：14-16,20,4.
替格瑞洛及氯吡格雷对急性冠脉综合征介入治疗后的疗效比较
Comparison of antiplatelet effects of ticagrelor and clopidogrel in patients with acute coronary syndrome
李晓红 1杨明 1韩凌 1陈欣 1陈萍 1胡文泽1
作者信息
- 1. 100038, 首都医科大学附属复兴医院心脏中心
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of ticagrelor and clopidogrel in patients with acute coronary syndrome (ACS). Methods Sixty-eight patients with ACS who were admitted to our department were enrolled in this study. All the patients were treated with percutaneous coronary intervention (PCI) before they were randomly divided into two groups: ticagrelor group and clopidogrel group(n =34 in each). After seven days, thrombelastography (TEG ) was used to compare the platelet inhibition rate between the two groups. After two months of follow-up, the major adverse events were compared between the two groups. Results After seven days of treatment, the platelet inhibition rate induced by ADP in ticagrelor group increased significantly (76.15±12.88)％ vs(51.08 ± 8.32) ％ compared with clopidogrel group. After two months of follow-up,there was one case of acute myocardial infarction, one death due to cardiovascular diseases and one case of gastrointestinal bleeding in clopidogrel group. One patient in ticagrelor group had medication suspended because of serious dyspnea. Conclusions For ACS patients who have received PCI, ticagrelor has a better anti platelet aggregation effect than clopidogrel, and it has proved to be safe.关键词
急性冠状动脉综合征/替格瑞洛/氯吡格雷/血栓弹力图/血小板抑制率Key words
acute coronary syndrome/ticagrelor/clopidogrel/thrombelastography/platelet inhibition rate分类
临床医学引用本文复制引用
李晓红,杨明,韩凌,陈欣,陈萍,胡文泽..替格瑞洛及氯吡格雷对急性冠脉综合征介入治疗后的疗效比较[J].武警医学,2018,29(1):14-16,20,4.
