西安交通大学学报（医学版）2018，Vol.39Issue(4)：459-462,478,5.DOI:10.7652/jdyxb201804002
缺血修饰性白蛋白与冠状动脉狭窄病变的相关性
Relationship between ischemia-modified albumin and coronary stenosis
摘要
Abstract
Objective To investigate the relationship between ischemia-modified albumin (IMA) and coronary artery stenosis in patients without myocardial infarction.Methods For this study we consecutively enrolled 345 patients who received coronary angiography (CAG).According to the results,the subjects were divided into coronary stenosis group (232 cases)and control group (113 cases)to investigate the the relationship of IMA and IMA/albumin (IMAr)with coronary stenosis.Results ① The levels of IMA and IMAr in coronary stenosis group were higher than those in control group (P＜0.001).② The IMA and IMAr were higher in single-branch and multi-branch lesion groups than in control group (P＜0.05),whereas there was no significant difference between single-branch lesion group and multi-branch lesion group (P＞0.05).③ In receiver operating characteristics curve analysis,the sensitivity of IMA and IMAr was 64.4% and 78.0%,respectively (AUC:0.653,0.705,P＜0.001)in predicting coronary stenosis.④ Multivariate logistic regression analysis showed that IMAr was an independent risk factor for coronary stenosis in patients without myocardial infarction (OR=73.05,P＜0.001).Conclusion IMA and IMAr are closely correlated with coronary stenosis and have a value in predicting coronary artery stenosis in patients without myocardial infarction.关键词
缺血修饰性白蛋白/冠心病/冠状动脉造影/白蛋白Key words
ischemia-modified albumin(IMA)/coronary atherosclerotic heart disease/coronary angiography(CAG)/albumin(Alb)分类
医药卫生引用本文复制引用
范雅洁,张春艳,张岩,王聪霞,郑阳,徐阳,韩拓,巩红,马维冬,刘晓唤,贾珊,胡艳超..缺血修饰性白蛋白与冠状动脉狭窄病变的相关性[J].西安交通大学学报（医学版）,2018,39(4):459-462,478,5.基金项目
国家自然科学基金资助项目(No.81273878).Supported by the National Natural Science Foundation of China (No.81273878) （No.81273878）
