西安交通大学学报（医学版）2018，Vol.39Issue(4)：466-470,5.DOI:10.7652/jdyxb201804004
血小板/淋巴细胞比值和中性粒细胞/淋巴细胞比值对药物洗脱支架内再狭窄的预测价值
Predictive values of the platelet to lymphocyte ratio and neutrophil to lymphocyte ratio for drug eluting stent restenosis
摘要
Abstract
Objective To investigate the predictive values of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR)before percutaneous coronary intervention (PCI)and a reexamination of coronary angiography (CAG)on the development of in-stent restenosis (ISR)in patients implanted with coronary drug eluting stent (DES).Methods For this study we enrolled 123 patients who had undergone successful drug eluting stent implantation (SI)and a further CAG reexamination.Another 45 patients with non-coronary heart disease (NC)served as controls.PLR and NLR were measured before DES implantation or CAG and compared between the groups.Patients in SI group were further divided into two subgroups based on the results of CAG reexamination:ISR group and no-ISR group.Hematologic data were reexamined before further CAG and compared between the subgroups.Receiver operator characteristic curve (ROC)was drawn to evaluate the predictive values of PLR and NLR for ISR.Results PLR and NLR before PCI or a further CAG were significantly higher in ISR group (34 patients)than in non-ISR group (89 patients,P＜0.05).Before PCI,the best cutoff value of PLR in screening restenosis was 107.20;the sensitivity and the specificity were 64.7% and 65.2%.The best cutoff value of NLR in screening restenosis was 2.72; the sensitivity and the specificity were 61.8% and 70.8%. Before CAG reexamination,the best cutoff value of PLR in screening restenosis was 160.08;the sensitivity and the specificity were 26.5% and 97.8%.The best cutoff value of NLR in screening restenosis was 2.08;the sensitivity and the specificity were 73.5% and 56.2%.Conclusion Both PLR and NLR before PCI or CAG reexamination can be predictors of ISR in patients implanted with DES.关键词
冠心病/支架内再狭窄/血小板/淋巴细胞比值/中性粒细胞/淋巴细胞比值/预测价值Key words
coronary heart disease/in-stent restenosis/platelet to lymphocyte ratio/neutrophil to lymphocyte ratio/predictive value分类
医药卫生引用本文复制引用
郑阳,葛淼,王聪霞,刘晓唤,马维冬,贾珊,范雅洁,姚智会,张春艳,张岩,胡艳超..血小板/淋巴细胞比值和中性粒细胞/淋巴细胞比值对药物洗脱支架内再狭窄的预测价值[J].西安交通大学学报（医学版）,2018,39(4):466-470,5.基金项目
国家自然科学基金资助项目(No.81273878).Supported by the National Natural Science Foundation of China (No.81273878) （No.81273878）
