西安交通大学学报（医学版）2018，Vol.39Issue(4)：471-474,4.DOI:10.7652/jdyxb201804005
冠心病合并亚临床甲减患者冠状动脉狭窄程度与内皮功能损伤的相关性
Correlation between the degree of coronary artery stenosis and endothelial dysfunction in patients with coronary heart disease and subclinical hypothyroidism
摘要
Abstract
Objective To study the correlation between coronary artery stenosis and endothelial dysfunction in patients with coronary heart disease and subclinical hypothyroidism.Methods According to the results of coronary angiography and thyroid function,the patients were divided into coronary heart disease with subclinical hypothyroidism (group A,n=71),coronary heart disease without subclinical hypothyroidism (group B,n=73), and normal coronary angiography (control group,n=59).The degree of coronary artery stenosis was evaluated by Gensini integral method.Fasting blood was taken to measure nitric oxide (NO),high sensitivity C reactive protein (hs-CRP),and endothelin (ET)to evaluate endothelial dysfunction.Results TC,TG,LDL-c,FT3,TSH,hs-CRP,ET and Gensini score were higher in Group A than in Group B and control group (P＜0.05).The level of NO in Group A and Group B were lower than that in control group (P＜0 .0 5).Multivariate Logistic regression analysis showed that age,TSH,ET and NO were independent risk factors for coronary heart disease.ET and NO levels in patients with coronary heart disease combined with subclinical hypothyroidism were correlated with Gensini scores (r=0.431,r=-0.383,P＜0.001).Conclusion Subclinical hypothyroidism may cause endothelial dysfunction in patients with coronary heart disease,which may increase cardiovascular risk in these patients.关键词
冠心病/亚临床甲减/内皮素/一氧化氮Key words
coronary heart disease/subclinical hypothyroidism/endothelin(ET)/nitric oxide分类
医药卫生引用本文复制引用
权晓慧,韩拓,徐阳,王聪霞,张春艳,张岩,郭瑄,贾珊,马维冬,郑阳,巩红..冠心病合并亚临床甲减患者冠状动脉狭窄程度与内皮功能损伤的相关性[J].西安交通大学学报（医学版）,2018,39(4):471-474,4.基金项目
国家自然科学基金资助项目(No.81273878) （No.81273878）
陕西省社会发展科技攻关项目(No.2016SF-260).Supported by the National Natural Science Foundation of China (No.81273878)and the Social Development Research Project of Shaanxi Province (No.2016SF-260) （No.2016SF-260）
