西安交通大学学报（医学版）2018，Vol.39Issue(4)：597-601,608,6.DOI:10.7652/jdyxb201804029
扶正消瘕方治疗胃癌前病变的临床疗效观察
The curative effect of Fuzhengxiaojia decoction on precancerous lesions of gastric cancer
摘要
Abstract
Objective To observe the curative effect of Fuzhengxiaojia decoction on precancerous lesion of gastric cancer (PLGC).Methods We randomly divided 44 patients with PLGC in our hospital into control group (n=22)and treatment group (n=22).The control group was given 4 Weifuchun tablets each time and three times per day and while the treatment group was given one Fuzhengxiaojia decoction of 400 mL besides the medication of the control group.They were treated for two courses,one course lasting for one month.Results Superoxide dismutase (SOD),malondialdehyde (MDA),glutathione peroxidase (GSH-Px),IgG,IgM and IgA in the two groups had no significant differences before treatment (P＞0.05).After treatment,compared with those in the control group,SOD (t=2.144,P=0.044)and GSH-Px (t=2.322,P=0.030)increased,while MDA(t=3.096, P=0.005),IgG(t=2.421,P=0.025),IgM(t=3.377,P=0.003)and IgA (t=2.521,P=0.020)decreased. The main symptom scores in the two groups did not significantly differ before treatment (P＜0.05).After treatment, compared with those in the control group,the scores for main symptoms like reduced food intake (t=3.924,P＜0.001),stomach noise (t=4.161,P＜0.001)and gastric or hypochondriac swelling (t=2.881,P＜0.009) decreased in the treatment group.The rate of effective cases was higher than that in the control group (χ2=4.539, P=0.033).Conclusion The effect of Weifuchun combined with Fuzhengxiaojia prescriptions in treating PLGC is better than Weifuchun alone,which is related to improving redox and immunoglobulin.关键词
扶正消瘕方/胃癌前病变/胃复春片/氧自由基/免疫球蛋白Key words
Fuzhengxiaojia/precancerous lesion of gastric cancer(PLGC)/Weifuchun tablet/oxygen free radical/immunoglobulin分类
医药卫生引用本文复制引用
孙涛,刘德山,朱玉,周兰,李昌玲,姚诗清,汪超,陈莉..扶正消瘕方治疗胃癌前病变的临床疗效观察[J].西安交通大学学报（医学版）,2018,39(4):597-601,608,6.基金项目
山东省中医药科技发展计划项目(No.2013-27) （No.2013-27）
山东大学基本科研业务费资助项目(No.2014QLKY07).Supported by the Scientific and Technological Development Planned Project of Traditional Chinese Medicine of Shandong Province (No.2013-27)and the Business Expense Project of Basic Scientific Research of Shandong University (No.2014QLKY07) （No.2014QLKY07）
