中国组织工程研究2018，Vol.22Issue(17)：2769-2774,6.DOI:10.3969/j.issn.2095-4344.0497
胚胎干细胞与遗传病模型的构建
Embryonic stem cells and construction of a genetic disease model
摘要
Abstract
BACKGROUND: Embryonic stem cells are pluripotent stem cells that can differentiate into all cell types and propagate themselves indefinitely in vitro, which have been used widely in biological research. OBJECTIVE: To summarize the culture methods of embryonic stem cells in vitro, as well as the significance, methods, clinical applications of embryonic stem cells as genetic disease models. METHODS: Relevant articles were searched in PubMed using the key words of "embryonic stem cell, genetic diseases" which appeared in the titles and abstracts. The latest articles were preferred. Totally 43 eligible articles were obtained for result analysis. RESULTS AND CONCLUSION: In the genetics study, embryonic stem cells have been widely used to construct monogenic and chromosome disease models, which can make up the limitations of animal and cell models. Models constructed by embryonic stem cells are conducive to the investigations on pathological processes and molecular mechanisms of genetic diseases. But there are also some ethic disputes on the use of embryonic stem cells, which need further studies.关键词
胚胎干细胞/遗传疾病/疾病模型/干细胞分类
医药卫生引用本文复制引用
邱佳慧,谭季春..胚胎干细胞与遗传病模型的构建[J].中国组织工程研究,2018,22(17):2769-2774,6.基金项目
2015年国家高技术研究发展计划(863计划)(2015AA020407) the National High-Technology Research and Development Plan of China (863 Program) in 2015, No. 2015AA020407 （863计划）
