中国组织工程研究2018，Vol.22Issue(18)：2910-2914,5.DOI:10.3969/j.issn.2095-4344.0854
银离子注入氧化钛涂层抗金黄色葡萄球菌的体外效果评价
In vitro evaluation of silver ion implantation into titanium dioxide coating against Staphylococcus aureus
摘要
Abstract
BACKGROUND: It is a challenge to seek for ideal anti-bacterial surface modification by which silver ions can have sustained and durable release. OBJECTIVE: To investigate the in vitro characteristics and effect of titanium dioxide coating with silver ion injection against Staphylococcus aureus . METHODS: There were four groups in the study: control group (pure titanium), titanium oxide coating group, low silver ion group (titanium oxide coating+30 minutes injection of silver ions), and high silver ion group (titanium oxide coating+60 minutes injection of silver ions). Characteristics of the implanted material in each group were observed using scanning electron microscope. Antibacterial efficacy for Staphylococcus aureus was assessed through bacterial instillation method, antibacterial ring test, and microbial growth curve. RESULTS AND CONCLUSION: Silver ions could be loaded onto the surface of the titanium dioxide coating through the silver ion implantation. Moreover, the number of silver ions on the coating surface and the antibacterial ability of the modified coating were both increased with the extension of injection time. Therefore, the silver ion implantation technology is beneficial to prepare inorganic antibacterial materials with strong and long-lasting antibacterial ability.关键词
银离子注入/表面改性/氧化钛涂层/抗菌剂/金黄色葡萄球菌/生长曲线/抑菌环/体外实验/生物材料分类
医药卫生引用本文复制引用
宋辉,贺韬,李亘,董宇启,张超..银离子注入氧化钛涂层抗金黄色葡萄球菌的体外效果评价[J].中国组织工程研究,2018,22(18):2910-2914,5.基金项目
上海市卫生和计划生育委员会资助项目(201440268) the Funded Project of Shanghai Municipal Health and Family Planning Commission, No.201440268 （201440268）
