畜牧兽医学报2018，Vol.49Issue(6)：1241-1248,8.DOI:10.11843/j.issn.0366-6964.2018.06.016
猪繁殖与呼吸综合征病毒类NADC30毒株FJZ03的致病性分析
Pathogenicity of a NADC30-like Strain FJZ03 of Porcine Reproductive and Respiratory Syndrome Virus Emerged in China
摘要
Abstract
The aim of this study was to explore the biological characteristics and pathogenic of a NADC30-like PRRSV.Thirty days old piglets confirmed to be free of PRRSV and PCV2 were inoculated with a NADC30-like PRRSV FJZ03 strain and a HP-PRRSV FJLYDX strain,respec-tively.The clinical symptoms,rectal temperature,virus excretion,virus loads in the sera,and tissues lesions were monitored and recorded.We found that FJZ03 strain could be rapidly replica-ted and developed higher titer of viremia in piglets.Moreover,the time of rectal temperatures rose and virus excretion in FJZ03 infected piglets were earlier than that of FJLYDX infected.Fur-thermore,piglets infected with FJZ03 displayed severe interstitial pneumonia and spleen atrophy.Cytokine test results showed that the cytokines concentrations of sera of FJZ03 infected piglets increased at different degrees.The IL-10 and TNF-α concentration in FJZ03 group was obvious higher than that of the FJLYDX group.Therefore,our results indicated that FJZ03 is pathogenic for piglets.关键词
猪繁殖与呼吸综合征病毒/NADC30-likePRRSV/致病性Key words
porcine reproductive and respiratory syndrome virus/NADC30-like PRRSV/patho-genicity分类
农业科技引用本文复制引用
刘建奎,范佳霖,魏春华,李艳,刘佳悦,马露露,虞慧芸,戴爱玲,杨小燕..猪繁殖与呼吸综合征病毒类NADC30毒株FJZ03的致病性分析[J].畜牧兽医学报,2018,49(6):1241-1248,8.基金项目
福建省科技重大专项(2014NZ0002-3) （2014NZ0002-3）
福建省自然科学基金(2016J01168) （2016J01168）
福建省大学生创新创业计划训练项目(201711312043) （201711312043）
