新医学2018，Vol.49Issue(6)：416-420,5.DOI:10.3969/j.issn.0253-9802.2018.06.008
2014～2016年尿路感染的病原菌及耐药分析
Analysis of the pathogenic bateria and drug resistance in patients with urinary tract infection from 2014 to 2016
摘要
Abstract
Objective To investigate the pathogenic bacteria and drug resistance in patients diag-nosed with urinary tract infection from 2014 to 2016,aiming to provide reference for clinical diagnosis and treatment. Methods The clean-catch midstream urine were collected and conventionally cultured from patients with urinary tract infection and the isolated bacteria were identified by the automatic VITEK 2 Compact and VITEK-MS. The antimicrobial susceptibility of staphylococcal strains was tested by using VITEK 2 Compact. The antimicrobial susceptibility of other strains was evaluated by using disk diffusion method. All the data were analyzed by WHONET 5. 6 software according to the CLSI 2016 breakpoints. Results A total of7 118 non-re-petitive clinical samples and 2 546 strains were collected from patients with urinary tract infection. The positive rate was 35. 8%. Gram-negative bacilli accounted for 76. 0%. The first five bacteria were Escherichia coli, Enterococcus faecalis,Klebsiella pneumoniae,Enterococcus faecium and Pseudomonas aeruginosa. The ESBL positive rates of E. coli and Klebsiella pneumoniae were 52. 8% and 45. 5%,respectively. Enterobacteriaceae possessed a relatively high sensitivity to imipenem,meropenem,amikacin,piperacillin/tazobactam and cef-operazone/sulbactam,and the resistance rates were below 10%. The percentage of Pseudomonas aeruginosa strains to all the antibiotics was below 20%except levofloxacin (33. 0%). The percentage of Enterococcus fae-cium resistant to most antibiotics was higher than that of Enterococcus faecalis. Seven Enterococcus sp. were found to be resistant to vancomycin and teicoplanin. Conclusion E. coli is the predominant pathogen in urina-ry tract infection. Drug resistance becomes a challenge. Extensive attention should be diverted to strengthen the surveillance for drug resistance and improve the rational use of antibiotics.关键词
尿路感染/病原菌/耐药性Key words
Urinary tract infection/Pathogen/Drug resistance引用本文复制引用
张伟,金炎,黄敏,郝莹莹,柳欣琦,李静,田季平,邵春红..2014～2016年尿路感染的病原菌及耐药分析[J].新医学,2018,49(6):416-420,5.基金项目
国家自然科学基金(81401696) （81401696）
山东省科技发展计划项目(2016GSF201078) （2016GSF201078）
