应用化学2018，Vol.35Issue(5)：491-499,9.DOI:10.11944/j.issn.1000-0518.2018.05.170280
卤素对核酸类药物的修饰与影响研究进展
Research Progress on Modification and Effects of Halogen on Nucleic Acid Drugs
摘要
Abstract
The halogenation is an invaluable approach for structural modification of drugs in medicine chemistry development.It increases the lipo-solubility,influences on the space charge distribution and improves their drug metabolic activity.Nucleic acid,as antiviral agent,antitumor agent,interferon inducer and immunopotentiator,can also be modified by halogenation.In this review we will discuss the effect on the bioactivity of modified nucleic acids on pyrimidines,purines and ribose by halogenation,and summarize the latest developments in drug research and development of modified nucleic acid.关键词
卤素/嘧啶/嘌呤/核糖/修饰/影响Key words
halogenation/pyrimidine/purine/ribose/modification/effects分类
化学化工引用本文复制引用
陈行,刘春冬,王建华..卤素对核酸类药物的修饰与影响研究进展[J].应用化学,2018,35(5):491-499,9.基金项目
重庆市自然科学基金重点项目(Cstc2013jjB0011)、重庆市社会事业与民生保障科技创新专项(Cstc2017shms-xdny0033)、重庆市社会事业与民生保障科技创新专项(Cstc2017shms-xdny80006)资助课题 Supported by the Natural Science Foundation of Chongqing,China(No.Cstc2013jjB0011),the Social Programs and Human Security in Chongqing Science(No.Cstc2017shms-xdny0033),the Technology Innovation Projects(No.Cstc2017shms-xdny80006) （Cstc2013jjB0011）
