应用化学2018，Vol.35Issue(5)：518-525,8.DOI:10.11944/j.issn.1000-0518.2018.05.170220
无催化剂、三组分一锅法合成2-氨基-3-氰基-4H-吡喃类化合物
Efficient Synthesis of 2-Amino-3-cyano-4 H-pyran Derivatives via Catalyst-Free One-Pot Tri-Component Reaction
摘要
Abstract
4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds are the key building blocks of numerous natural products and represent a "drug-like" structural motif with a broad spectrum of applications in organic synthesis and medicinal chemistry.In this paper,a convenient one-pot three-component strategy was conducted successfully under catalyst-free condition employing water as reaction medium and ethanol as co-solvent.Three kinds,over fifty 2-amino-3-cyano-4H-pyran derivatives were synthesized in good to excellent yields by the condensation of a series of aromatic aldehydes with malononitrile and different 1,3-dicarbonyl compounds.Broad substrate scope,systematic characterization,eliminated catalyst,mild reaction condition,simple purification procedure are the best advantages in this methodology.关键词
多组分反应/无催化剂/水/4H-吡喃/绿色合成Key words
multi-component reaction/catalyst-free/water/4H-pyran derivatives/green synthesis分类
化学化工引用本文复制引用
吕乐,毛胜雪,李非,朱小磊,吕成伟..无催化剂、三组分一锅法合成2-氨基-3-氰基-4H-吡喃类化合物[J].应用化学,2018,35(5):518-525,8.基金项目
国家自然科学基金(21403100)和辽宁省博士科研启动基金(20141100)资助项目 Supported by the National Natural Science Foundation of China (No.21403100),the Doctoral Scientific Research Foundation of Liaoning Province(No.20141100) （21403100）
