应用化学2018，Vol.35Issue(5)：538-543,6.DOI:10.11944/j.issn.1000-0518.2018.05.170279
香豆素基Schiff碱类化合物的合成及抗氧化性能
Synthesis and Antioxidant Activity of Coumarin Schiff Base Derivatives
摘要
Abstract
Two Coumarin Schiff base derivatives were synthesized from 2,3,4-trimethoxybenzaldehyde by demethylation,Knoevenagel and nucleophilic addition reaction.Structures of the corresponding products were elucidated through the analysis of 1H NMR and MS spectra.The antioxidant activities of two derivatives were evaluated by quenching 2,2′-diphenyl-1-picrylhydrazyl radical(DPPH),2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonate)ammonium salt cationic radical(ABTS),and hydroxyl free radical.The result shows that the target compounds can quench the three types of free radicals.Compared to 7,8-dimethoxy-3-aminocoumarin,two coumarin Schiff base derivatives have higher quenching activity for DPPH and hydroxyl free radical and have higher antioxidant activity.关键词
香豆素基Schiff碱/抗氧化Key words
coumarin Schiff base/antioxidant分类
化学化工引用本文复制引用
丰翠,闵曼,谢蓉蓉,任建辉,陈琳..香豆素基Schiff碱类化合物的合成及抗氧化性能[J].应用化学,2018,35(5):538-543,6.基金项目
广东省科技计划项目(2012B061700040) （2012B061700040）
广东省医学科学技术研究基金项目(201618171249486)资助 Supported by the Science and Technology Planning Project of Guangdong Province,China(No.2012B061700040) （201618171249486）
the Medical Science and Technology Research Fund Project of Guangdong Province,China(No.201618171249486) （No.201618171249486）
