中国肺癌杂志2018，Vol.21Issue(6)：445-450,6.DOI:10.3779/j.issn.1009-3419.2018.06.04
LC-3和P62在非小细胞肺癌中的表达及其临床特征分析
Expression and Clinical Significance of LC-3 and P62 in Non-small Cell Lung Cancer
摘要
Abstract
Background and objective LC-3 and P62, two of important autophagy-related proteins, were reported highly expressed in many kinds of human malignancies and associated with outcomes of the pa-tients. The purpose of this study was to investigate the expression status of LC-3 and P62 in non-small cell lung cancer patients and define the clinical-pathologic features. Methods 66 cases of non-small cell lung cancer pa-tients were employed. The expression of LC-3 and P62 were detected by immunohistochemistry. Results LC-3 was positive stained in 27 out of 66 cases (40.9%) and P62 was positive stained in 43 out of 66 cases (65.2%). LC-3 positive staining was more frequently in squamous cell carcinoma patients (P＜0.05); while P62 positive staining was more frequently in late-stage adenocarcinoma patients with metastasis (P＜0.05). There was a sig-nificant negative correlation between LC-3 and P62 expressions in non-small cell lung cancer tissues (rs=-0.065, P＜0.001). Kaplan-Meier analysis showed that patients with positive LC-3 expression had favorable clinical out-comes compared with the patients with negative LC-3 expression (P＜0.05). Conclusion LC-3 and P62 showed abnormal expression in non-small cell lung cancer tissues, suggesting that autophagy is involved in the occur-rence and development of NSCLC.关键词
LC-3/P62/自噬/非小细胞肺癌/免疫组织化学Key words
LC-3/P62/Autophagy/Non-small cell lung cancer/Immunohistochemistry引用本文复制引用
王璁,李永文,李颖,宫颢,张洪兵,袁茵,李伟婷,刘红雨,陈军..LC-3和P62在非小细胞肺癌中的表达及其临床特征分析[J].中国肺癌杂志,2018,21(6):445-450,6.基金项目
本研究受国家自然科学基金(No.81773207, No.81372306)、天津自然科学基金重点项目(No.16JCZDJC34200)、天津市创新平台专项市级重点实验室建设项目(No.16PTSYJC00160)和天津市创新团队基金的资助.This study was supported by the grants from the National Natural Science Foundation of China (to Jun CHEN)(No.81773207) (to Hongyu LIU) (No.81372306), the Science and Technology Support Key Program of Tianjin (to Jun CHEN) (No.16JCZDJC34200), the Municipal Key Laboratory Construction Project of Tianjin Innovative Platform Special (to Hongyu LIU) (No.16PTSYJC00160) and Special Support Program for High Tech Leader & Team of Tianjin (to Jun CHEN). （No.81773207, No.81372306）
