中国光学2018，Vol.11Issue(3)：401-419,19.DOI:10.3788/CO.20181103.0401
应用于生物医疗领域的碳纳米点及其复合物
Carbon nanodots and their composites for biomedical applications
摘要
Abstract
As an emerging carbon nanomaterial , carbon nanodots(CNDs) have many advantages such as low preparation cost, small size, low toxicity, high biocompatibility, good water solubility, easy modification, u-nique photophysical properties , and exhibit unique advantages and application prospects in the field of bio-medicine.Taking advantage of the abundant surface functional groups , carbon nanodots can interact with func-tional theranostic agents such as targeting ligands , contrast agents in medical imaging , nucleic acids, chemical drugs, photosensitizers, and photothermal conversion reagents to form composites .Currently, bioluminescent imaging applications of carbon nanodots and their composites in biomedical theranostic fields such as medical imaging, gene therapy, chemotherapy, photothermal therapy, and photodynamic therapy are widely studied and reported.These researches are of great significance to the development of medical theranostic reagents based on carbon nanodots and their clinical advancement , and provide a novel drug system for the advance-ment of individualized , visualized, non-invasive, and minimally invasive diagnosis and treatment of major hu-man diseases.This paper focuses on the design , construction and performance of carbon nanodots and their composites used in the field of theranostics .In addition, the research progress of the reported carbon nanodots based theranostic reagents in the biomedical field is discussed and summarized .关键词
碳纳米点/碳纳米点复合物/诊断治疗试剂/纳米医疗Key words
carbon nanodots/carbon nanodot complexes/theranostic agents/nanomedicine分类
化学化工引用本文复制引用
王晓筠,李波,陈力,李迪,曲松楠,李志民..应用于生物医疗领域的碳纳米点及其复合物[J].中国光学,2018,11(3):401-419,19.基金项目
国家自然科学基金项目( No.51602304 ) （ No.51602304 ）
吉林省教育厅"十三五"科学研究规划项目( No. JJKH20180232KJ)Supported by National Natural Science Foundation of China (No.51602304) （ No. JJKH20180232KJ）
the 13th Five-Year Plan for Edu-cation Department of Jilin Province (No.JJKH20180232KJ) （No.JJKH20180232KJ）
