中国光学2018，Vol.11Issue(3)：513-530,18.DOI:10.3788/CO.20181103.0513
微流控SERS芯片及其生物传感应用
Microfluidic SERS chip and its biosensing applications
摘要
Abstract
With excellent integrability and flexible operability , microfluidic chips have been developed rapid-ly.Among them, Surface-enhanced Raman Spectroscopy (SERS) has become a widely used detection tech-nique due to its ultrasensitivity , unique fingerprint spectrum and narrow spectroscopic bands .The SERS mi-crofluidic chip integrates the advantages of the SERS detection technology and the microfluidic chip .On the one hand, it provides an efficient platform for the repeatability and reliability of the SERS detection method . On the other hand , it promotes function expansion for microfluidic chips .The SERS microfluidic chips have broad application prospects in the fields of biomolecule detection , cell capture and even tissue simulation .In this review, the principle of SERS is briefly introduced , and the construction of SERS microfluidic chip and its applications in biosensing and detection are emphatically summarized .Finally, the problems and development direction of the research are proposed .关键词
表面增强拉曼光谱/微流控/微流控芯片/生物传感Key words
surface-enhanced raman spectroscopy/microfluidic/SERS microfluidic chip/biosensing分类
数理科学引用本文复制引用
王志乐,王著元,宗慎飞,崔一平..微流控SERS芯片及其生物传感应用[J].中国光学,2018,11(3):513-530,18.基金项目
国家自然科学基金(No.61535003) （No.61535003）
国家重点基础研究发展计划(No.2015CB352002)Supported by the Natural Science Foundation of China (No.61535003) （No.2015CB352002）
the National Key Basic Research Pro-gram of China(No.2015CB352002) （No.2015CB352002）
