中国康复理论与实践2018，Vol.24Issue(6)：686-695,10.DOI:10.3969/j.issn.1006-9771.2018.06.013
重复经颅磁刺激对卒中后失语语言功能重组的影响:基于功能磁共振的研究
Effect of Repeated Transcranial Magnetic Stimulation on Reorganization of Aphasia after Stroke: A Study Based on Functional Magnetic Resonance Imaging
摘要
Abstract
Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the brain functional reorga-nization of aphasia after stroke, with functional magnetic resonance imaging (fMRI). Methods From January, 2017 to February, 2018, six eligible stroke patients with aphasia were recruited in experimental group, and nine age-gender matched healthy adults were recruited in healthy control group. Subjects in both groups received task-fMRI, and the experimental group was assessed with Chinese version of Western Aphasia Battery (WAB) examination before and after rTMS treatment. Four patients underwent rTMS at the right inferior frontal gyri pars triangularis marked by neuro-navigation-guided system, 1 Hz, five times per week for two weeks. The fMRI data were processed by SPM 12. The differences of brain activation and voxel changes be-tween two groups were compared. The fMRI data including the differences in brain activation, voxel volume and activation voxel indices (AVI) and WAB scores were analyzed before and after rTMS. Results The cerebral hemisphere activation in the experimental group was higher than that of the healthy control group, including the regions of interest (ROI) such as bilateral supplementary motor area and middle frontal gyrus, and the non-ROI (n-ROI) such as left praecuneus, left postcentral gyrus, right hippocampus, right paracingulate cor-tex, etc., while the activation reduced in the areas of left pars triangularis and n-ROI such as left calcarine fissure cortex, left gyrus lingualis, the right anterior cingulate and the paracingulate cortex. Cases 1 and 2 had shorter course of disease, smaller lesion volume, and activation increased in bilateral cerebral hemispheres before treat-ment. AVI showed that their hemispheric dominance was right, and activation reduced in bilateral cerebral hemi-sphere after treatment, but the high-efficiency language function area of ROI, such as the left pars triangularis, turned from inactive to active, and the hemispheric dominance lateralized from right to left, with the improve-ment of language function. For the case 3 and case 4, the disease courses were longer, the lesions sizes were larg-er, and both cerebral hemisphere activations were reduced before treatment. AVI showed that the hemispheric dominance of case 3 was right and was left in case 4. After treatment, bilateral cerebral hemispheres were activat-ed more than before, and the hemispheric dominance of language function was in the right hemisphere; the left middle frontal gyrus and right middle temporal gyrus were activated from no activation before treatment in case 3. The activation of the supplemental motor area on the right side was increased. In case 4, there was no activa-tion in ROI before treatment. After treatment, the bilateral supplementary motor area, right pars opercularis, and the right middle temporal gyrus were activated. Conclusion Low-frequency rTMS could improve the language function by optimizing bilateral cerebral hemisphere brain areas related with language function in patients with aphasia after stroke.关键词
脑卒中/失语症/功能磁共振成像/经颅磁刺激/功能重组Key words
stroke/aphasia/functional magnetic resonance imaging/transcranial magnetic stimulation/functional reor-ganization分类
医药卫生引用本文复制引用
邱国荣,丘卫红,邹艳,冯小欢,武惠香,陈兆聪,康庄..重复经颅磁刺激对卒中后失语语言功能重组的影响:基于功能磁共振的研究[J].中国康复理论与实践,2018,24(6):686-695,10.基金项目
1.广东省自然科学基金项目(No. 2016A030313327) （No. 2016A030313327）
2.广东省科技计划项目(No. 2016A020215226) （No. 2016A020215226）
3.广州市科技计划项目(No. 201607010185) （No. 201607010185）
4.国家自然科学基金青年科学基金项目(No. 81401869)Natural Science Foundation of Guangdong Province (No. 2016A030313327), Science and Technology Planning Project of Guangdong Province (No. 2016A020215226), Science and Technology Program of Guangzhou (No. 201607010185) and National Science Foundation for Young Scholars (No. 81401869) （No. 81401869）
