中国临床药理学杂志2018，Vol.34Issue(9)：1011-1013,3.DOI:10.13699/j.cnki.1001-6821.2018.09.001
阿加曲班注射液联合高压氧治疗急性缺血性脑卒中的临床研究
Clinical trial of argatroban injection combined with hyperbaric oxygen in the treatment of acute ischemic stroke
摘要
Abstract
Objective To observe the clinical efficacy and safety of argatroban injection combined with hyperbaric oxygen in the treatment of acute ischemic stroke (AIS).Methods A total of 78 patients with AIS were randomly divided into control and treatment groups with 39 cases per group.Control group received argatroban injection 60 mg per time,continuous intravenous infusion for day 1 to 2,and on the third day,adagiban was given 10 mg per time,bid,intravenous drip for 3 hours.Treatment group was treated with hyperbaric oxygen for 60 min with the pressure was 0.2 MPa,oxygen concentration was pure oxygen,once a day,on the basis of control group.Two groups were treated for 10 days.The clinical efficacy,levels of inflammatory cytokines,copeptin (CPP) and N terminal pro brain natriuretic peptide (NT-proBNP),Chinese stroke clinical neurological deficit scale (NDS) and European stroke scale (ESS) score,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 84.62％ (33 cases/39 cases) and 71.79％ (28 cases/39 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:CPP were (2.78 ± 0.36) and (4.19 ± 0.57) pmol · L-1,NT-proBNP were (127.34±18.08) and (214.54 ±30.16) pmol · L-1,NDS scores were (12.84 ±1.77) and (18.28 ±2.42) points,ESS scores were (68.44 ± 9.74) and (62.18 ± 8.62) points,the differences were statistically significant (all P ＜0.01).There were no significant adverse drug reactions occurred in two groups during the treatment.Conclusion Argatroban injection combined with hyperbaric oxygen has a definitive clinical efficacy and safety in the treatment of AIS.关键词
阿加曲班注射液/高压氧/急性缺血性脑卒中/安全性Key words
argatroban injection/hyperbaric oxygen/acute ischemic stroke/safety分类
医药卫生引用本文复制引用
孙荣道,余丹,杨国帅..阿加曲班注射液联合高压氧治疗急性缺血性脑卒中的临床研究[J].中国临床药理学杂志,2018,34(9):1011-1013,3.基金项目
海南省自然科学基金资助项目(2012-812174) （2012-812174）
