中国临床药理学杂志2018，Vol.34Issue(9)：1018-1021,4.DOI:10.13699/j.cnki.1001-6821.2018.09.003
硫酸镁联合硝苯地平缓释片治疗妊娠期高血压综合征的临床研究
Clinical trial of magnesium sulfate combined with extended release nifedipine tablet in the treatment of pregnancy induced hypertension syndrome
摘要
Abstract
Objective To investigate the clinical effect of magnesium sulfate combined with extended release nifedipine tablets in the treatment of pregnancy induced hypertension syndrome (PIH) and its effect in hemodynamic parameters and antioxidant capacity of uterine artery.Methods Seventy-four pregnant women with PIH were randomly divided into control group and treatment group,37 cases in each group.The control group was treated with magnesium sulfate injection 5 g,intravenous injection + magnesium sulfate injection 15 g,1-1.5 g · h-1 intravenous drip,qd.On the basis of control group,treatment group was given extended release nifedipine tablets 10 mg,tid,orally.All patients were treated for 7 d.The changes of blood pressure,urine protein,antioxidant capacity index,uterine artery blood flow parameters,clinical efficacy and adverse pregnancy outcomes were compared between the two groups.Results After treatment,the clinical effect in treatment group and control group were 89.19％ (33 cases/37 cases)and 78.38％ (29 cases/37 cases),with significant difference (P ＜ 0.05).After treatment,the systolic blood pressure (SBP) in treatment group and control group were(130.08 ± 14.77) and (141.27 ± 16.14)mmHg,the diastolic blood pressure (DBP) were (80.44 ± 9.29) and (92.73 ± 10.88) mmHg,the urinary protein were (604.17 ± 72.76) and (839.26 ± 103.62) mg,levels of malondialdehyde (MDA) were (20.13 ± 2.62) and (24.68 ± 3.47) μmol · L-1,uterine artery pulsatility indexes (PI) were 2.09 ± 0.26 and 2.31 ± 0.30,resistance indexes (RI) were 0.66 ± 0.08 and 0.81 ±0.10,peak systolic velocity / end diastolic velocity (S/D) were 2.28 ±0.29 and 2.69 ±0.32,maximum systolic blood flow velocity (Vmax) were (50.17 ± 7.01) and (45.94 ± 6.46) cm · s-1,minimum diastolic blood flow velocity (Vmin) were (9.36 ± 1.31) and (7.48 ± 1.01) cm · s-1,all with significant difference (P ＜ 0.01).The adverse pregnancy outcomes were postpartum hemorrhage,premature delivery and neonatal asphyxia in treatment group,the adverse pregnancy outcomes were postpartum hemorrhage,premature delivery,placental abruption and neonatal asphyxia in control group.The incidence of adverse pregnancy outcomes in treatment group and control group were 10.81％ (4 cases/37 cases)and 29.73％ (11 cases/37 cases),there was no statistical difference between the two groups(P ＞ 0.05).Conclusion Magnesium sulfate combined with extended release nifedipine tablets had significant clinical effect in the treatment of PIH,and had positive significance for the pregnancy outcome,which may be related to the regulation of uterine hemodynamics and antioxidant capacity.关键词
妊娠期高血压综合征/硫酸镁/硝苯地平/抗氧化能力Key words
pregnancy induced hypertension/magnesium sulfate/nifedipine/antioxidant capacity分类
医药卫生引用本文复制引用
戴小萍..硫酸镁联合硝苯地平缓释片治疗妊娠期高血压综合征的临床研究[J].中国临床药理学杂志,2018,34(9):1018-1021,4.基金项目
海南省自然科学基金资助项目(1426360.10A1006) （1426360.10A1006）
