中国临床药理学杂志2018，Vol.34Issue(9)：1022-1024,1028,4.DOI:10.13699/j.cnki.1001-6821.2018.09.004
噻托溴铵联合舒利迭治疗支气管哮喘的临床研究
Clinical trial of tiotropium combined with sulpiride in the treatment of patients with bronchial asthma
摘要
Abstract
Objective To investigate the clinical effect of tiotropium combined with seretide in the treatment of patients with bronchial asthma.Methods Ninety cases of bronchial asthma were randomly divided into treatment group and control group,each group 45 cases.Control group was given seretide accuhaler.On the basis of control group,treatment group was given tiotropium inhalation powder spray treatment,18 μg each time,1 times a day.All patients were treated for 12 weeks.The pulmonary function changes,eosinophil cationic protein (ECP),interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),the clinical effect and treatment satisfaction were compared between the two groups.Results After treatment,total effective rates in control group and treatment group were 82.22％ (37 cases/45 cases),97.78％ (44 cases/45 cases),with significant difference (P ＜ 0.05).After treatment,the levels of forced expiratory volume in one second (FEV1) in treatment and control groups were (1.46 ± 0.32),(1.08 ± 0.25) L,the levels of peak expiratory flow (PEF) were (4.35± 1.12),(3.77 ± 1.02) L · s-1,the levels of forced vital capacity (FVC) were(2.18 ±0.36)％,(1.71 ± 0.31) ％,all with significant difference (all P ＜ 0.05).After treatment,the levels of ECP in treatment and control groups were (160.60 ± 20.30),(289.70 ± 25.60) ng · mL-1,the levels of IL-6 were (28.90 ± 5.70),(53.70 ± 8.80) pg · mL-1,the levels of TNF-α were (10.40 ± 2.30),(17.60 ± 3.10) ng · mL-1,all with significant difference (all P ＜ 0.05).The adverse drug reactions in treatment group were palpitations,hoarseness,with the incidence of 11.11％ (5 cases/45 cases).The adverse drug reactions in control group were hoarseness,with the incidence of 8.89％ (4 cases/45 cases),with no significance difference (P ＞ 0.05).Conclusion The clinical effect of tiotropium combined with seretide in the treatment of patients with bronchial asthma is great,and can increase patients' treatment satisfaction.关键词
噻托溴铵/舒利迭/支气管哮喘Key words
tiotropium bromide/seretide/asthma分类
医药卫生引用本文复制引用
陈墩顺,陈飞,宋国强,卢火佺..噻托溴铵联合舒利迭治疗支气管哮喘的临床研究[J].中国临床药理学杂志,2018,34(9):1022-1024,1028,4.基金项目
浙江省医药卫生计划基金资助项目(2011ZHB012) （2011ZHB012）
