中国临床药理学杂志2018，Vol.34Issue(9)：1025-1028,4.DOI:10.13699/j.cnki.1001-6821.2018.09.005
珂立苏联合鼻塞持续气道正压通气治疗新生儿呼吸衰竭的临床研究
Clinical trial of Kelisu combined nasal continuous positive airway pressure for neonatal respiratory ailure
摘要
Abstract
Objective To evaluate the effect of calf pulmonary surfactant (Kelisu) combined nasal continuous positive airway pressure (NCPAP) in the treatment of neonatal respiratory failure (NRF).Methods Forty-eight NRF in our hospital were selected,and divided into the control group (n =24) and the treatment group (n =24) according to random number table.Control group were given NCPAP therapy,treatment group were treated with Kelisu 70-100 mg · kg-1 combined NCPAP.After using Kelisu 0,6,12,24 h,the results of arterial blood gas analysis,respiratory function indexes,clinical effects and incidence of complications in the two groups were compared.The adverse drugs reaction (ADR)were investigated.Results After 12 h treatment,the level of PaO2 in treatment group with (75.7 ± 1.6) mmHg was higher than the control group with (70.8 ± 1.8) mmHg.The level of PaCO2 in treatment group with (51.2 ± 1.7) mmHg was lower than the control group with (53.8 ± 0.7) mmHg.The time of the oxygen curein in treatment group with(180.65 ± 21.64)h was shorter than the control group with (217.52 ±19.58)h.The incidence of ADR in treatment group with 16.7％ (4 cases/24 cases) was lower than the control group with 45.8％ (11 cases/24 cases).Camparison between control group and the treatment group on the factors,the differences were statistically significant(all P ＜ 0.05).Conclusion Endotracheal dripping of calf pulmonary surfactant combined with NCPAP is an effective treatment for NRF,and had good safety.关键词
新生儿呼吸衰竭/鼻塞持续气道正压/肺泡表面活性物质/动脉血气指标Key words
neonatal respiratory failure/nasal continuous positive airway pressure/pulmonary surfactant/arterial blood gas index分类
医药卫生引用本文复制引用
党嘉文,董文斌,雷小平,何娜,郭琳..珂立苏联合鼻塞持续气道正压通气治疗新生儿呼吸衰竭的临床研究[J].中国临床药理学杂志,2018,34(9):1025-1028,4.基金项目
四川省卫生和计划生育委员会科研课题基金资助项目(150069) （150069）
