中国临床药理学杂志2018，Vol.34Issue(9)：1089-1091,3.DOI:10.13699/j.cnki.1001-6821.2018.09.023
四逆散对创伤后应激障碍及睡眠障碍大鼠睡眠潜伏期的影响
Effects of Sinisan on sleep latency in rats with post traumatic stress and sleep disorder
摘要
Abstract
Objective To study the effects of sleep latency to the intervention of Sinisan in rats with post-traumatic stress and sleep disorder (PTSD).Methods Fifty SD rats were divided equally into 5 groups:sham operation group,model group,negative control group group,positive control group and experimental group.PTSD model was made by claustrophobia,but not in sham operation group.The model group was not given the drug,the negative control group was given equal volume 0.9％ NaC1,and the positive control group was given paroxetine hydrochloride 0.42 mg · mL-1.The experimental group was perfused with the decoction of Sinisan (containing 0.24 g · mL-1) 10 mL · kg-1.The drug was administered 1 h before the stress model was administered once a day for a total of 7 d.After intervention on the 7th day,nonrapid eye movements sleep (NREMS) and eye movements sleep (REMS) were detected.Results The REMS and NREMS of sham operation group and model group were respectively (8.66 ± 3.04),(23.27 t 10.15) min;(65.90 ± 25.08),(109.36 ± 43.43) min,the differences between groups were statistically significant(all P ＜ 0.01);the result suggest that difficulty in falling asleep appears in rats after modeling.The REMS and NREMS of the positive control group and the experimental group were respectively (8.17 ±2.29),(6.83 ±2.84) min;(162.29 ±46.19),(195.24 ±67.96) min.Comparison between the drugs groups and model group,the difference was statistically significant (P ＜0.05,P ＜0.01).These Results suggested that both paroxetine hydrochloride and Sinisan can significantly promote the sleep of rats.Conclusion Traditional Chinese medicine compound Sinisan can obviously promote the rats with sleep disorder caused by PTSD.关键词
四逆散/创伤后应激障碍/睡眠潜伏期/睡眠障碍Key words
Sinisan/post-traumatic stress disorder/sleep latency/sleep disorder分类
医药卫生引用本文复制引用
李越峰,司昕蕾,边甜甜,牛江涛,曹瑞,严兴科..四逆散对创伤后应激障碍及睡眠障碍大鼠睡眠潜伏期的影响[J].中国临床药理学杂志,2018,34(9):1089-1091,3.基金项目
国家自然科学基金资助项目(81460611) （81460611）
国家教育部科学技术研究重点基金资助项目(212186) （212186）
甘肃省自然科学基金资助项目(2010:1010RJZA212 （）
2014:145RJZA076) （）
甘肃省财政厅高校基本科研业务费专项基金资金项目(2013-2) （2013-2）
兰州市科技计划基金资金项目(2014-1-188) （2014-1-188）
甘肃省中医药管理局科研课题基金资金项目(GZK-2015-57) （GZK-2015-57）
