中国临床药理学杂志2018，Vol.34Issue(10)：1140-1143,4.DOI:10.13699/j.cnki.1001-6821.2018.10.003
细胞色素P4501A1基因多态性对多西他赛联合卡培他滨治疗转移性乳腺癌的临床疗效的影响
Influence of cytochrome P (CYP) 1A1 gene polymorphism on the clinical outcomes of docetaxel plus capecitabine in the treatment of metastatic breast cancer
摘要
Abstract
Objective To investigate the association between cytochrome P (CYP) 1A1 polymorphism and clinical outcomes in metastatic breast cancer (MBC) patients treated by docetaxel plus capecitabine.Methods Sixty-nine MBC patients who were treated with docetaxel plus capecitabine were included in this study.And 79 single nucleotide poly morphisms (SNPs) in CYP450,whose minor allele frequency (MAF) ≥ 10％ were genotyped.Association between rs1048943 (Ile462Val) and clinical outcomes were analyzed.Results Only one SNP,CYP1A1 rs1048943 was sigrnificantly associated with progress free survival (PFS),the median PFS of GA/GG genotype patients and wild type AA genotype patients were 8.3 months (95 ％ CI:5.4-11.8) and 5.3 months (95％ CI:2.9-7.6),with significant difference (P ＜0.05).Multivariate analysis conrirmed its prognostic significance for PFS (HR =0.4,P ＜ 0.05).Conclusion CYP1A1 rs1048943 polymorphism is probably a potential prognostic marker for survival outcomes treated with docetaxel plus capecitabine chemotherapy in MBC patients.关键词
乳腺癌/细胞色素P450/多态性Key words
breast cancer/cytochrome P450/polymorphism分类
医药卫生引用本文复制引用
黄钰,李长江,袁启东,沈杰,位臻..细胞色素P4501A1基因多态性对多西他赛联合卡培他滨治疗转移性乳腺癌的临床疗效的影响[J].中国临床药理学杂志,2018,34(10):1140-1143,4.基金项目
国家自然科学基金资助项目(81641141) （81641141）
