中国临床药理学杂志2018，Vol.34Issue(10)：1151-1154,4.DOI:10.13699/j.cnki.1001-6821.2018.10.006
美洛昔康联合硫酸氨基葡萄糖治疗骨关节炎的临床研究
Clinical trial of meloxicam combined with glucosamine sulfate in the treatment of patients with osteoarthritis
摘要
Abstract
Objective To investigate the clinical efficacy of meloxicam combined with glucosamine sulfate in the treatment of patients with osteoarthritis.Methods Ninety cases of knee osteoarthritis were randomly divided into control group and treatment group,each group 45 cases.Control group was given meloxicam tablets 7.5 mg,bid,oral.On the basis of control group,treatment group was treated with glucosamine sulfate capsules 0.5 g,tid,oral.All the patients were treated for 6 weeks.The clinical symptoms,signs,knee joint motor function and pain indexes of all patients were evaluated before and after treatment.The blood samples and joint fluid specimens were collected,to determine the matrix metalloproteinase-3 (MMP-3),matrix metalloproteinase-13 (MMP-13) and prostaglandin E2 (PGE2) levels by enzyme linked immunosorbent assay (ELISA).The clinical efficacy and adverse drug reactions in two groups were compared.Results After treatment,the levels of Lequesne indexes in treatment group and control group were 5.78 ± 3..04 and 8.24 ± 3.62,Lysholm scores were 85.82 ± 10.01 and 72.46 ± 13.58,VAS scores were 2.45 ± 1.08 and 3.86 ± 1.17,serum MMP-3 levels were (114.69 ± 13.54) and (130.52 ± 16.48) ng · L-1,serum MMP-13 levels were (141.06 ± 21.55) and (179.82 ± 24.37) ng · L-1,serum PGE2 levels were(69.82 ± 18.67)and(91.30 ±20.09)ng · L-1,joint fluid MMP-3 levels were(17.89 ±5.12) and (23.10 ±5.46)ng · L-1,joint fluid MMP-13 levels were(27.35 ±6.52)and(38.47 ±6.85)ng · L-1,joint fluid PGE2 levels were (82.16 ± 22.64) and (118.02 ± 23.41) ng · L-1,all with significant difference (all P ＜ 0.05).The improvement rates of control group and treatment group were 73.33％ (33 cases/45 cases),91.11％ (41 cases/45 case),with significant difference (P ＜ 0.05).No adverse drug reactions occurred during the treatment.Conclusion The clinical effect of meloxicam combined with glucosamine sulfate in the treatment of knee osteoarthritis is exact,the treatment is conducive to the improvement of clinical symptoms,can reduce serum MMP-3,MMP-13,PGE2 levels,with high safety.关键词
美洛昔康/硫酸氨基葡萄糖/骨关节炎Key words
meloxicam/glucosamine sulfate/osteoarthritis分类
医药卫生引用本文复制引用
韩宏德,蒋家正,张恒林,桑龙,韩贵宾..美洛昔康联合硫酸氨基葡萄糖治疗骨关节炎的临床研究[J].中国临床药理学杂志,2018,34(10):1151-1154,4.基金项目
海南省卫生厅基金资助项目(琼卫-2013资助-036号) （琼卫-2013资助-036号）
