中国临床药理学杂志2018，Vol.34Issue(10)：1191-1194,4.DOI:10.13699/j.cnki.1001-6821.2018.10.016
基于变异系数的模糊物元模型评价当归不同提取部位润肠通便的效果
Evaluating the effect of moisturizing intestine to relaxing the bowels of Angelica's different extracted parts with Fuzzy Matter-element model based on variation coefficient weight
摘要
Abstract
Objective To screen the effective parts of loosening bowel and relieving constipation in mice from different extracted parts of Angelica and to investigate the utilization of fuzzy matter-element model in evaluating the effect of moisturizing intestine to relaxing the bowels of Angelica's different extracted parts.Methods Kunming mice were randomly divided into 11 groups,including normal group,model group (constipation),positive control group (Nongsuo Danggui Wan and Runchang Wan:20 μL · g-1),medicated group consisted by 7 different extracted parts of Angelica (3.4 g · kg-1 Angelica herbs).The constipation model was formed by the compound difenoxate solution 5.0 mg · kg-1 and finished after 30 min.We used the first defecation time as well as the dark stool points in 6 h,the weight of stools,the pushing rate of intestine and intestinal moisture as detection index and then using fuzzy matter-element model on variation coefficient weight to evaluate the comprehensive effect of different extract parts of Angelica.Results Time of first black stool discharge as well as the dark stool points in 6 h,the weight of stools,the pushing rate of intestine and intestinal moisture in model group were (241.90 ± 48.10) min,(9.00 ± 5.40) count,(149.10 ± 86.80) mg,(48.90 ± 16.50) ％,(1.45 ± 0.16) g,respectively.The 70％ ethanol impregnation part (part 2) on the factors were (172.60 ± 40.70) min,(17.30 ± 4.50) count,(223.70 ± 63.40) mg,(73.70 ± 13.10) ％,(1.71 ± 0.18) g,respectively.The difference between part 2 and model group was statistically significant in the factors (P ＜0.05 or P ＜0.01).Combining with the result of the value of Euclid approach degree,the maximum is 0.71 (part 2:70％ alcohol impregnation part).Conclusion The 70％ alcohol impregnation part is the effective part of loosening bowel to relieve constipation in mice.The method and model can be used to objectively evaluate the effect of moisturizing intestine to relaxing the bowels of Angelica' s different extracted parts.关键词
当归不同提取部位/润肠通便/模糊物元模型/变异系数权重Key words
Angelica's different extracted parts/loosening bowel to relieve constipation/fuzzy matter-element model/variation coefficient weight分类
医药卫生引用本文复制引用
任国瑾,朱顺娟,夏鹏飞,罗倩,韦凌霞,杨挡,赵磊..基于变异系数的模糊物元模型评价当归不同提取部位润肠通便的效果[J].中国临床药理学杂志,2018,34(10):1191-1194,4.基金项目
国家自然科学基金资助项目(81660577) （81660577）
甘肃省自然科学基金资助项目(148RJZA064) （148RJZA064）
甘肃省中医药管理局科研基金资助项目(GZK-2014-77) （GZK-2014-77）
甘肃中医药大学校企合作基金资助项目(2015-1) （2015-1）
甘肃中医学院中青年科研基金资助项目(ZQ2014-2) （ZQ2014-2）
陇药产业发展专项基金资助项目(甘财经(2015)164号) （甘财经(2015）
