中国临床药理学杂志2018，Vol.34Issue(10)：1203-1205,3.DOI:10.13699/j.cnki.1001-6821.2018.10.019
四逆散对创伤后应激障碍及睡眠障碍大鼠海马区神经元放电波幅的影响研究
Effect of Sinisan on hippocampal neurons discharge amplitude in rats with post-traumatic stress disorder and sleep disorder
摘要
Abstract
Objective To study the function mechanism of the Sinisan on hippocampal neuron discharge amplitude in rats with post-traumatic stress disorder and sleep disorder.Methods Fifty SD rats were divided into blank group,model group,negative control group,positive control group and experimental group.The blank group did not copy the model,did not receive treatment,the normal feeding.The repetitive post-traumatic stress disorder model was induced by current stimulation in model group,but not treated.Negative control group was given equal volume of 0.9％ NaC1.Positive control group was given paroxetine hydrochloride 0.42 mg · mL-1 and experimental group was given Sinisan,containing crude drug 0.24 g · mL-1.The rats were administered with 10 mL · kg-1,once a day,for 7 d.Theneural coding on amplitude in hippocampal CA1/CA3 were detected by M-NEMEA after the treatment.Results The amplitude of the wave amplitude in model group were 63.73 ± 5.80,63.24 ± 6.29,significantly lower than those of negative control group,which were 90.95 ± 5.94,91.16 ± 8.18 (P ＜ 0.01).And the wave amplitude in positive control group were 87.12 ± 8.14,87.21 ± 7.94,and were 91.63 ± 7.30,91.39 ± 7.64 in experimental group,had significant difference with those in model group (P ＜ 0.01).Conclusion The Sinisan have significant positive effect on hippocampal neuron discharge amplitude.关键词
四逆散/创伤后应激障碍/海马区/放电波幅Key words
Sinisan/post-traumatic stress disorder/hippocampus/discharge amplitude分类
医药卫生引用本文复制引用
李越峰,司昕蕾,曹瑞,牛江涛,张泽国,边甜甜,严兴科..四逆散对创伤后应激障碍及睡眠障碍大鼠海马区神经元放电波幅的影响研究[J].中国临床药理学杂志,2018,34(10):1203-1205,3.基金项目
国家自然科学基金资助项目(81460611) （81460611）
国家教育部科学技术研究重点基金资助项目(212186) （212186）
甘肃省自然科学基金资助项目(2010:1010RJZA212 （）
2014:145RJZA076) （）
甘肃省财政厅高校基本科研业务费专项基金资助项目(2013-2) （2013-2）
兰州市科技计划基金资助项目(2014-1-188) （2014-1-188）
甘肃省中医药管理局科研课题基金资助项目(GZK-2015-57) （GZK-2015-57）
