中国临床药理学杂志2018，Vol.34Issue(10)：1230-1233,4.DOI:10.13699/j.cnki.1001-6821.2018.10.026
细胞色素P450 2C19基因多态性对服用他莫昔芬乳腺癌患者疗效影响的Meta分析
Influence of CYP2C19 polymorphisms on efficacy of tamoxifen on the breast cancer patients: a Meta-analysis
摘要
Abstract
Objective To assess the relationship between cytochrome P450 2C19 (CYP2C19) polymorphisms and effect of the tamoxifen (TAM) in the treatment of beast cancer by performing a meta-analysis.Methods The relevant DataBase were systematically searched for clinical studies on the CYP2C19 polymorphisms of TAM for breast cancer patients.The literatures were screened according to the inclusion and exclusion criteria.Then,the data were extracted and the methodologically quality of included studies were also examined,recurrence-free survival (RFS) as an evaluation indicator.Meta-analysis was carried out by using RevMan 5.3 software from Cochrane Network.Results A total of 8 studies involving 3261 subjects were included.The results of meta-analysis showed that there was no significant difference in CYP2C19 * 2 gene mutation for RFS of breast cancer patients using TAM (OR =1.13,95％ CI:0.92-1.40,P ＞ 0.05),as well as CYP2C19 * 17 (OR =1.22,95％ CI:0.94-1.57,P ＞ 0.05).Conclusion The CYP2C19 polymorphisms might be not associated with the effect of TAM on the breast cancer patients.关键词
细胞色素P4502C19/他莫昔芬/乳腺癌/系统评价/Meta分析Key words
cytochrome P450 2C19/tamoxifen/beast cancer/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
过怿赟,谢海棠,黄晓晖..细胞色素P450 2C19基因多态性对服用他莫昔芬乳腺癌患者疗效影响的Meta分析[J].中国临床药理学杂志,2018,34(10):1230-1233,4.基金项目
国家自然科学基金资助项目(81173134) （81173134）
皖南医学院中青年科研基金资助项目(WK2015F11) （WK2015F11）
