中国临床药理学杂志2018，Vol.34Issue(10)：1250-1252,3.DOI:10.13699/j.cnki.1001-6821.2018.10.032
子宫内膜异位症患者腹腔液中磷脂酶A2表达及其临床意义
Expression of phospholipase A2 in peritoneal fluid of patients with endometriosis and its clinical significance
摘要
Abstract
Objective To evaluate the expression and clinical significance of phospholipase A2 (PLA2) expression in celiac fluid of endometriosis patients and its clinical significance.Methods Forty three cases of endometriosis patients without chronic pelvic inflammatory disease were selected as treatment group (n =43),30 cases of patients with ovarian benign teratoma were selected as control group (n =30).The levels of secreted phospholipase A2 (sPLA2) in peritoneal fluid of two groups were compared,to determine the tissue localization of cytosolic phospholipase A2 (cPLA2),and to compare the expression of cPLA2 in patients with different stages of endometriosis.Results The levels of sPLA2 in peritoneal fluid of treatment group and control group were 578.4,544.4 ng· L-1,with significant difference (P ＜ 0.05).The cPLA2 is mostly located on cytoplasm of glandular epithelial cells,blood vessel endothectopic endometrium.The levels of cPLA2 in endometriosis group in Ⅲ-Ⅳ stage was (0.70 ± 0.30) ng · L-1,significantly higher than that of Ⅰ-Ⅱ stage,which was (0.27 ±0.19) ng · L-1 (P ＜0.05).Conclusion Both the levels of sPLA2 and cPLA2 are highly expressed in endometriosis patients,with the progress of the disease,the degree of PLA2 expression increased.PLA2 may play an important role in the activation of endometriosis.关键词
磷脂酶A2/子宫内膜异位症/炎症Key words
hospholipase A2/endometriosis/inflammation分类
医药卫生引用本文复制引用
包秋芳,曲军英..子宫内膜异位症患者腹腔液中磷脂酶A2表达及其临床意义[J].中国临床药理学杂志,2018,34(10):1250-1252,3.基金项目
福建省自然科学基金资助项目(2010J01105) （2010J01105）
