中国临床药理学杂志2018，Vol.34Issue(10)：1253-1256,4.DOI:10.13699/j.cnki.1001-6821.2018.10.033
直接口服抗凝药患者实验室检测的研究现状
Research status of laboratory tests for patients with direct oral anticoagulants
摘要
Abstract
In recent years,the use of direct oral anticoagulants (DOACs) have been gradually accumulated in clinical practice.In specific cases,the DOACs blood concentration of patients are needed to be clearly defined in order to assist in further diagnosis and treatment.Therefore,through the study of literature retrieval of DOACs laboratory test at home and abroad,we intended to explore detection method of four kinds of DOACs (dabigatran,rivaroxaban,apixaban and edoxaban).Meanwhile we also discussed the use of DOACs detection and its effect on coagulation function detection in emergency or during the perioperative period.Finally,the results turned out that patients with dabigatran can detect the blood concentration by activated partial thromboplastin time,diluted thrombin time and ecarin clotting time.Factor Xa activity assay can be used for patients taking direct a factor Xa inhibitor,and high sensitivity of prothrombin time detection are especially suitable for rivaroxaban patients.关键词
达比加群/利伐沙班/阿哌沙班/依度沙班/直接口服抗凝药/实验室检测Key words
dabigatran/rivaroxaban/apixaban/edoxaban/direct oral anticoagulant/laboratory testing分类
医药卫生引用本文复制引用
王哲,谢秋芬,向倩,崔一民..直接口服抗凝药患者实验室检测的研究现状[J].中国临床药理学杂志,2018,34(10):1253-1256,4.基金项目
国家自然科学基金面上基金资助项目(81673509,81573504) （81673509,81573504）
国家重点研发计划精准医疗课题基金资助项目(2016YFSF090494) （2016YFSF090494）
北京市自然科学基金资助项目(7171012) （7171012）
