中国免疫学杂志2018，Vol.34Issue(6)：887-891,5.DOI:10.3969/j.issn.1000-484X.2018.06.017
急性HIV感染者γδ T细胞及其细胞亚群的表型分析
Phenotype analysis of γδ T cell and their subsets in acute HIV-infected patients
摘要
Abstract
Objective:To analyze the phenotypes of γδ T cell in acute HIV-infected patients,and to clarify the role of γδ T cell in acute HIV infection(AHI). Methods:The expressions of CD38,programmed cell death protein-1(PD-1),CD160,CD95 and tumor necrosis factor-related apoptosis inducing ligand-death receptor 5 ( TRAIL-DR5 ) were detected by using flow cytometry. Results:Compared with healthy controls,the frequencies of Vδ1 T cells were significantly increased and the frequencies of Vδ2 T cells were de-creased,however,the frequencies of total γδ T cells were not significantly changed in acute HIV-infected patients. The frequencies of CD38+γδ T cells,CD38+Vδ1 T cells and CD38+Vδ2 T cells were significantly increased compared with healthy controls. Moreover, compared with healthy controls,the frequencies of PD-1+γδ T cells and DR5+γδ T cells were increased,but the expression of PD-1 and DR5 on Vδ1 and Vδ2 T cells were not significantly changed. However,the frequencies of CD38+Vδ1 T cells,CD160+Vδ1 T cells,PD-1+Vδ1 T cells,CD95+Vδ1 T cells and DR5+Vδ1 T cells were significantly increased compared with Vδ2 T cells in acute HIV-infected patients. Conclusion:Activation,inhibitor and apoptosis markers are highly expressed on γδ T cells,especially on Vδ1 T cells in acute HIV-infected patients,suggest that Vδ1 T cells play more important roles in acute HIV infection and disease progression.关键词
γδ T细胞/急性HIV感染/免疫活化/抑制性分子Key words
γδ T cell/Acute HIV infection/Immune activation/Inhibitor分类
医药卫生引用本文复制引用
吴江,王蕊,画伟,王桂芳,李群辉,李珍..急性HIV感染者γδ T细胞及其细胞亚群的表型分析[J].中国免疫学杂志,2018,34(6):887-891,5.基金项目
本文为国家自然科学基金( 81501731 ) 、北京市科技计划项目( D161100000416003 ) 和北京市艾滋病研究重点实验室(BZ0089). （ 81501731 ）
