中国全科医学2018，Vol.21Issue(17)：2138-2142,5.DOI:10.3969/j.issn.1007-9572.2018.00.058
NLRP3炎性小体与动脉粥样硬化相关性研究进展
Recent Advances in the Relationship between NLRP3 Inflammasome and Atherosclerosis
摘要
Abstract
NLRP3 inflammasome is a polyprotein complex formed by the activation of pattern recognition receptor. Activated NLRP3 inflammasome can transform pro-caspase-1 into active caspase-1,which promotes the maturation and secretion of IL-1β and IL-18,and then triggers the inflammatory response of the body.Atherosclerosis is the basis of the pathogenesis of cardiocerebral vascular disease,which is a serious threat to human health.Recent studies show that atherosclerosis is a chronic inflammatory reactive disease,inflammasome plays a key role in the inflammatory response of atherosclerosis,and NLRP3 inflammasome is closely related to the formation of atherosclerosis.This article reviews the activation mechanism of NLRP3 inflammasome and its relationship with atherosclerosis.关键词
动脉粥样硬化/NLRP3炎性小体/炎症Key words
Atherosclerosis/NLRP3 inflammasome/Inflammation分类
医药卫生引用本文复制引用
池天鹤,孙经武,康文,吴雨卉,杜清,蒋双强..NLRP3炎性小体与动脉粥样硬化相关性研究进展[J].中国全科医学,2018,21(17):2138-2142,5.基金项目
山东省自然科学基金联合专项(ZR2014HL010) （ZR2014HL010）
