Abstract
Objective To investigate the mechanism of action of modified dietary pattern on reducing the levels of inflammatory markers and hypertension management in overweight or obese middle-aged and older people with hypertension from Zhangfang Village of Beijing's Fangshan District based on our previous studies.Methods This trial was implemented from May 21st to July 1st,2017.From the database of middle-aged and older villagers(245 cases aged 45-75)of Zhangfang Village of Beijing's Fangshan District,54 overweight or obese cases with grade 1 hypertension were sampled based on the inclusion and exclusion criteria and were randomized into group A(n=27)eating a standardized balanced diet and group B(n=27)eating a standardized balanced diet supplemented by anti-atherosclerotic powdered foods.Then,according to the completion status of trial,30(15 in group A and 15 in group B)were included in the final analysis.We collected the data about the levels of inflammatory markers〔high-sensitivity C-reactive protein(hs-CRP),soluble intercellular adhesion molecule-1(sicam-1), vascular cell adhesion molecule-1(VCAM1),nuclear factor-kappa B(NF-κB),integrin,E-selectin,interleukin-6 (IL-6),interleukin 10(IL-10),toll-like receptor 2(TLR2),toll-like receptor 4(TLR4)〕measured before the intervention(T0),during the intervention(T1)and at the end of the intervention(T2)and dietary inflammatory index (DII)at T0 and T2.Results The DII in group B was lower than that of group A(P＜0.05).The DII in group B decreased significantly at T2 compared with at T0(P＜0.05).The intervention program and duration exerted interactive effects on IL-10 (P＜0.05).Intervention program produced significant main effects on NF-κB,integrin and E-selectin(P＜0.05).And intervention duration had main effects on sicam-1,VCAM1,NF-κB,integrin,E-selectin,IL-6 ,and TLR2(P＜0.05). At T0,the levels of NF-κB,integrin and E-selectin were lower in group B compared with group A,when at T2,the levels of NF-κB and integrin were still lower in group B(P＜0.05).For group A,compared with at T0,at T1,only the level of integrin decreased significantly,but at T2,besides integrin,the levels of NF-κB,E-selectin,IL-6 decreased significantly(P＜0.05). Moreover,TLR2 at T2 declined significantly compared with at T1(P＜0.05).For group B,compared with at T0,sicam-1, VCAM1 and integrin decreased significantly at T1(P＜0.05),and at T2,besides the above 3 markers,IL-6 also decreased significantly(P＜0.05).Furthermore,sicam-1,NF-κB,E-selectin,and TLR2 were much lower compared with at T1(P＜0.05). Conclusion After eating a balanced diet and a modified balanced diet(by adding anti-atherosclerotic powdered foods), the middle-aged and elderly overweight or obese patients with hypertension presented reduced levels of inflammatory markers, increased anti-inflammatory capabilities as well as good hypertension management outcome.关键词
高血压/膳食/炎症/膳食炎性指数/炎性指标Key words
Hypertension/Diet/Inflammation/Dietary inflammatory index/Inflammatory index分类
医药卫生
