中国实验动物学报2018，Vol.26Issue(3)：280-286,7.DOI:10.3969/j.issn.1005-4847.2018.03.003
不同脑发育时期大鼠认知功能的比较
Comparison of the cognitive function in rats at different brain developmental stages
摘要
Abstract
Objective To investigate the relationship between different brain developmental stages and changes of cognitive function in rats. Methods 1-month, 2-month and 8-month-old rats were selected to imitate the juvenile, adolescent and adulthood, respectively, and their behavioral functions were compared. The reward operant conditioning and Morris water maze task were used to investigate the differences in exploration interest, executive and recognition ability, spatial learning and memory of the rats at different ages. Results In the reward operant conditioning and Morris water maze task, there was no significant difference in the cognitive function between 1-month and 2-month-old rats. In the reward conditioning phase, the nose pokes numbers of 8-month-old rats were significantly decreased compared with the 1-month-old rats (P＜ 0. 01). There was no significant difference in nose pokes accuracy. During the operant conditioning phase, the lever press numbers and accuracy of 8-month-old rats were significantly decreased ( P ＜ 0. 05 or P ＜ 0. 01) and the press latency was longer (P ＜ 0. 05). At the phase of visual identification, the press and reward numbers, and the visual identification index were significantly decreased ( P ＜ 0. 05 or P ＜ 0. 01). In the Morris water maze test, compared with the 1-month-old rats, the total swimming distance and escape latency of the 8-month-old rats were significantly increased (P＜ 0. 05), as well as average swimming speed ( P ＜ 0. 05 or P ＜ 0. 01) in spatial learning phage. In spatial memory phage, the swimming distance and time spent in the target quadrant were obviously decreased (P＜ 0. 01). Conclusions The cognitive functions of rats at different brain developmental stages are different. The juvenile and adolescent rats have similar cognitive functions, but 8-month-old adult rats appear decline in the exploration interest, executive and recognition ability, and spatial learning and memory function.关键词
脑发育/认知/探索兴趣/执行操作能力/辨识能力/空间记忆Key words
brain development/cognition/exploration interest/executive ability/recognition ability/spatial learning and memory分类
生物科学引用本文复制引用
董黎明,吕静薇,姜宁,陈善广,刘新民..不同脑发育时期大鼠认知功能的比较[J].中国实验动物学报,2018,26(3):280-286,7.基金项目
中国医学科学院创新工程(No. 2016-I2M-2-006) （No. 2016-I2M-2-006）
国家自然科学基金(No. 81773930) （No. 81773930）
中国科学技术部项目(No. 2017ZX09301029).Funded by CAMS Initiative for Innovative Medicine (No.2016-I2M-2-006), the National Natural Science Foundation of China (No. 81773930), the Ministry of Science and Technology of China (No. 2017ZX09301029). （No. 2017ZX09301029）
