中国比较医学杂志2018，Vol.28Issue(1)：16-22,7.DOI:10.3969/j.issn.1671-7856.2018.01.003
组胺对抑郁症大鼠运动欲望与空间记忆能力的影响
Effects of histamine on the motor activity and spatial memory ability in depressive rats
摘要
Abstract
Objective To explore the effect of histamine on neurons in the hippocampal C1 area of SD rats and the behavior of depressive SD rats. Methods The effect of histamine on the discharge frequency of neurons in hippocampal C1 area was observed by in vitro extracellular recording of brain slices. The effect of endogenous histamine released to hippocampal neurons was observed through in vivo extracellular recording after the hypothalamus was electrically stimulated. In addition, the changes of motor activity and the ability of spatial memory of the rats with depression after microinjection of histamine into the hippocampal C1 area were observed by open-field test and Morris water maze test. Results The results of in vitro extracellular recording of brain slices showed that the hippocampal neurons were excited by histamine via H1 receptors rather than H receptors in a concentration dependent manner. The results of in vivo extracellular recording showed that endogenous histamine had a bidirectional effect, which means a short-term excitatory effect followed by a long-term inhibitory effect on the hippocampal neurons. After injected with histamine in the hippocampal C1 area,关键词
组胺/海马/抑郁症模型大鼠/空间记忆/运动欲望Key words
histamine/hippocampus/rat model of depression/spatial memory/motor activity分类
医药卫生引用本文复制引用
何叶成,姚娟,陈尚,李东印..组胺对抑郁症大鼠运动欲望与空间记忆能力的影响[J].中国比较医学杂志,2018,28(1):16-22,7.基金项目
江苏省卫生厅省教研室立项课题(编号: J201403) （编号: J201403）
江苏省青蓝工程资助项目. （）
