中国比较医学杂志2018，Vol.28Issue(1)：113-117,5.DOI:10.3969/j.issn.1671-7856.2018.01.020
脑内表达的CYP450基因参与内源性物质代谢研究进展
Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances
摘要
Abstract
Cytochrome P450 (CYP450) is a superfamily of heme-thiolate proteins, which is involved in the metabolism and activation of various endogenous and exogenous substances, including food, drugs and pollutants. Previous studies of the CYP450 genes mainly focused on their function in drug metabolism. However, in recent years, studies have found that CYP450 are also involved in the development and progression of various diseases, including Parkinson's disease (PD), cancer, cardiomyopathy and heart failure (HF). By far, the process and related mechanisms of CYP450 in the metabolism of endogenous substances in brain tissues has not been clarified yet. In this paper, we summarized the research progress of CYP450 genes involved in the metabolism of endogenous substances, in order to provide a new idea for the exploration of the functions of CYP450 genes expressed in the brain.关键词
脑组织/细胞色素P450/内源物质/代谢Key words
brain tissues/cytochrome P450/endogenous substances/metabolism分类
医药卫生引用本文复制引用
杨辛兰,吕丹,张连峰..脑内表达的CYP450基因参与内源性物质代谢研究进展[J].中国比较医学杂志,2018,28(1):113-117,5.基金项目
北京市自然科学基金(编号: 5172027) （编号: 5172027）
国家自然科学基金(编号: 31301932). （编号: 31301932）
